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MetabolomicsOral-gut microbiome and plasma metabolome reveal incremental restratification of coronary artery disease from the clinical gray zone
Clinical prediction models have been widely applied for risk stratification of coronary artery disease (CAD), yet approximately 20% to 40% of screened individuals fall into the intermediate-risk interval and face a decision gap. Here, we adopted a two-stage validation design. In the first stage, a c...
2026-08-31 | MTBLS15425 | MetaboLights
ProteomicsExploring the molecular mechanism of dihydroartemisinin regulating spleen immunity based on proteomics and phosphoproteomic
The molecular mechanisms through which dihydroartemisinin (DHA) induces immunomodulation in vivo remain unclear. Herein, DHA-regulated proteins and their phosphorylation profiles were identified and characterized, in the spleens of mice, using proteomics and phosphoproteomic approaches. We found tha...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-29 | PXD030353 | Pride
Dihydroartemisinin Phosphoproteomic Proteomics Immunomodulatory activity 
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
ProteomicsProteome overview of exosome derived from plasma of cows infected with Mycobacterium bovis
Bovine tuberculosis (bTB), primarily caused by Mycobacterium bovis (M. bovis), is a globally zoonotic disease with significant economic impacts. Plasma exosomes have been extensively used for investigating disease processes and exploring biomarkers. While mass spectrometry (MS)-based proteomic analy...
ORGANISM(S): Bos Taurus 
2024-06-17 | PXD048167 |
ProteomicsProteome landscape of mouse primordial germ cells
Primordial germ cells (PGCs) are precursors of both male and female gametes as fundamental materials for organism development. The transcriptome, methylome and chromatin accessibility profiles of PGCs in both mice and humans have been recently reported. However, little is known about the characteris...
ORGANISM(S): Mus Musculus 
2020-05-18 | PXD019222 |
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap
ORGANISM(S): Homo Sapiens 
2024-08-28 | PXD055421 |
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, To investigate the function of ZMYND11 in prostate cancer, We performed Co-IP and mass-spectometry (MS) analysis of ZMYND11.
ORGANISM(S): Homo Sapiens 
2024-08-27 | PXD055219 |
ProteomicsProteomics of esophageal squamous cell carcinoma
study the differentially expressed proteins in esophageal squamous cell carcinoma
ORGANISM(S): Homo Sapiens 
2020-07-06 | PXD020230 |
ProteomicsCirculating Exosomes proteome of Colorectal Cancer Based on Rapid DIA-MS
Early screening is essential for the treatment of colorectal cancer (CRC). Concerns are rising regarding liquid biopsy due to its low invasiveness and reproducibility, especially when tissue samples are not available. Recent reports suggest that tumor-specific proteins may be stably expressed in exo...
ORGANISM(S): Homo Sapiens 
2019-10-20 | PXD015921 |
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