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ProteomicsA Chemoproteomic Approach toward Probing the Interactomes of Perfluoroalkyl Substances
Poly- and perfluoroalkyl substances (PFASs) are widely used in industrial products and consumer goods. Due to their extreme-ly recalcitrant nature and potential bioaccumulation and toxicity, exposure to PFASs may result in adverse health outcomes in humans and wildlife. In this study, we developed a...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025757 | Pride
Pfass Probe 
ProteomicsPreclinical Evaluation of seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines
Glioblastoma multiforme (GBM) is among the most lethal primary brain tumors and is characterized by significant cellular heterogeneity and resistance to conventional therapies. This study investigates the efficacy of seco-duocarmycin SA (seco-DSA), a novel DNA alkylating agent. Initial investiga-tio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061023 | Pride
Proof of concept Glioblastoma multiforme Resistance Cellular mechanisms Seco-dsa Duocarmycin Potency 
ProteomicsEffective Enrichment Strategy Using Boronic Acid Functionalized Mesoporous Graphene Silica Composites for Intact Glycopeptide Analysis in Human Serum
The heterogeneity and low abundance of protein glycosylation present challenging barriers to the analysis of intact glycopeptides, which is key to comprehensively understanding the role of glycosylation in an organism. Efficient and specific enrichment of intact glycopeptides could help greatly with...
ORGANISM(S): Human 
2021-04-28 | MSV000087324 | MassIVE
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