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ProteomicsAorta-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease
Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete understanding of the patho...
ORGANISM(S): Homo sapiens (Human) 
2021-09-11 | PXD026303 | Pride
Mitochondrial dynamics Human aortic smooth muscle cells Organ-on-a-chip Thoracic aortic aneurysm Bicuspid aortic valve 
TranscriptomicsExpression data from macrophages isolated from lupus NZB/W mouse kidneys prenephritic, nephritic or after complete remission.
Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune comple...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-27045 | biostudies-arrayexpress
TranscriptomicsTGF-b signaling and response
This work evaluates new and specific therapeutic targets and molecular diagnostic markers connected to the TGF-b response system in chronic fibrotic diseases.
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-579 | biostudies-arrayexpress
GenomicsGenome-wide maps of the total and lysine methylated enriched pools of peroxisome proliferating activated receptor gamma (pparg) co-activator 1 alpha (ppargc1a) in Hepa 1-6 cells
We report the application of single nucleotide sequencing technology for high-throughput profiling of ppargc1a in mouse hepatome cells (Hepa1-6). By obtaining 1.2 billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide maps of ppargc1a sin mouse hepatoma cells. We ...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-57852 | biostudies-arrayexpress
TranscriptomicsThe Role of Macrophages in the Development of Human Renal Allograft Fibrosis in the First Year after Transplantation
The aim of this study was to investigate the role of infiltrating macrophages in renal allograft fibrosis. Forty-six protocol renal allograft biopsies obtained one-year after transplantation were stained with Sirius Red to quantify fibrosis and double stained with CD68 and CD206 to identify the prop...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-GEOD-65326 | biostudies-arrayexpress
TranscriptomicsComparison of Glomerular and Podocyte mRNA Profiles in eNOS-/- Diabetic Mice Induced by Streptozotocin
We compared mRNA profiles of isolated glomeruli versus sorted podocytes between diabetic and control mice. IRG mice crossed with eNOS-/- mice were further bred with podocin-rTTA and TetON-Cre mice to permanently label podocytes before the diabetic injury. Diabetes was induced by injection of strepto...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79291 | biostudies-arrayexpress
GenomicsCharles R. Bronfman Institute for Personalized Medicine (IPM) BioBank Genome Wide Association Study of Cardiovascular, Renal and Metabolic Phenotypes

The Institute for Personalized Medicine (IPM) Biobank Project is a consented, EMR-linked medical care setting biorepository of the Mount Sinai Medical Center (MSMC) drawing from a population of over 70,000 inpatients and 800,000 outpatient visits annually. MSMC serves diverse local commun...

phs000388.v1.p1 | EGA
UnknownGenetic and Phenotype Analysis of a Chinese Cohort of Infants and Children With Epilepsy.
Not available
S-EPMC9091957 | biostudies-literature
UnknownRapid humoral immune responses are required for recovery from haemorrhagic fever with renal syndrome patients.
Not available
S-EPMC8284976 | biostudies-literature
TranscriptomicsComprehensive role of Zfp217 in m6A methylation [RIP-seq]
Many transcriptional and epigenetic networks must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. Here, we explore the role of Zfp217and Mettl3 as RNA-binding proteins. Identification and charac...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-65733 | biostudies-arrayexpress
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