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MetabolomicsNew aspects characterizing nonobese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model

Nonalcoholic fatty liver disease (NAFLD) is a major public health problem due to the high incidence affecting approximately one-third of the world’s population. NAFLD is usually linked to obesity and excessive weight. A subset of patients with NAFLD express normal or low body mass index; thus, th...

2024-02-27 | MTBLS9365 | MetaboLights
TranscriptomicsNucleosome positioning changes during human embryonic stem cell differentiation.
Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human embryonic stem cells (hESCs) transition to nascent mesoderm and...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-45877 | biostudies-arrayexpress
UnknownSelf-management intervention for long-term indwelling urinary catheter users: randomized clinical trial.
Not available
S-EPMC4268883 | biostudies-literature
MetabolomicsChromosome‐level genome of Camellia lanceoleosa provides a valuable resource for understanding genome evolution and self‐incompatibility

The section Oleifera (Theaceae) has attracted attention for the high levels of unsaturated fatty acids found in its seeds. Here, we report the chromosome-scale genome of the sect. Oleifera using diploid wild Camellia lanceoleosa with a final size of 3.00 Gb and an N50 s...

2022-07-14 | MTBLS3769 | MetaboLights
TranscriptomicsGenome-wide analysis of matched microRNA-mRNA time-course data after androgen injection to prostate cancer LNCaP cell line
Androgen receptor (AR) signalling pathway plays an important role in carcinogenesis and development of prostate cancer. The involvement of microRNA (miRNA) in this process is still largely unknown. In this study, we performed a matched miRNA-mRNA time-course expression profiling to reveal androgen r...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-21245 | biostudies-arrayexpress
TranscriptomicsDNA methylation and gene expression changes during human embryonic stem cell differentiation
Investigate the genome-wide DNA methylation and gene expression changes during human embryonic stem cell differentiation. hESCs (H1 and H13) DNA samples for 3 different differentian stage (D0, undifferentiated;D21, 21 days after undirected differentiation; D90, 90 days after undirected differentiati...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-32371 | biostudies-arrayexpress
TranscriptomicsmicroRNA differential regulations gradually mediate genomic instability during cervical intraepithelial neoplasia progression.
In most cases human papillomavirus (HPV) infections are cleared from the cervical cells by the immune system itself, but in a few cases, where there is persistent HPV infection, it can lead to cervical intraepithelial neoplasia (CIN) progression and ultimately invasive cervical carcinoma. The cytopa...
ORGANISM(S): Homo sapiens 
2013-11-02 | E-GEOD-51993 | biostudies-arrayexpress
ProteomicsClinical proteomics analysis using Data Independent Acquisition-Mass Spectrometry (DIA-MS) identified classifiers for molecular characterization of Lymphoma
In this study, we conducted a proteomics analysis on 109 fresh-frozen lymph node samples from clinical patients, covering a comprehensive suite of lymphoma subtypes including B-NHL, T-NHL, HL, Lymphadenitis, Tumor metastatic lymph node (TLN), and Non-neoplastic lymph node (TNM: N0).
ORGANISM(S): Homo Sapiens 
2020-01-15 | PXD017096 |
ProteomicsNAPT, an unbiased approach for sequential analysis of protein N- and C- terminome
Robust analysis of both protein N- and C-termini can reveal novel N- and C-degrons that modify protein stability and shape the eukaryotic proteome. Herein, we designed a workflow, termed LysargiNase-assisted Analysis of Protein N- and C-Terminome (NAPT) by sequential and selective separating N- and ...
ORGANISM(S): Homo Sapiens 
2022-04-11 | PXD030791 |
ProteomicsSelective autophagy regulates chloroplast protein import to promote plant stress tolerance
This data from co-immunoprecipitation (co-IP) using YFP-Trap magnetic beads followed by mass spectrometry, using protein extracts prepared from the chloroplast fraction of cells expressing YFP-ATG8or YFP-HA.
ORGANISM(S): Arabidopsis Thaliana 
2023-03-14 | PXD040844 |
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