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UnknownCK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells.
The dysregulation of Bcl-x alternative splicing is associated with tumor development and chemoresistance. However, the underlying molecular mechanisms of Bcl-x splicing are still not well-defined. Here, we demonstrated that casein kinase 1ε (CK1ε) was involved in the regulation of Bcl-x alternative ...
S-EPMC12391806 | biostudies-literature
UnknownParkin Inhibits Static Mechanical Pain by Suppressing Membrane Trafficking of Mechano-transducing Ion Channel TACAN.
Not available
S-EPMC9068839 | biostudies-literature
TranscriptomicsAn essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.
Type I interferons were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of interferon antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-13530 | biostudies-arrayexpress
UnknownQuantitative assessment of the effect of pre-gestational diabetes and risk of adverse maternal, perinatal and neonatal outcomes.
Pregnancies complicated by pre-gestational diabetes (PGD) are associated with a higher rate of adverse outcomes, including an increased rage of preterm delivery, pregnancy-induced hypertension, pre-eclampsia, caesarean section, perinatal mortality, stillbirth, shoulder dystocia, macrosomia, small fo...
S-EPMC5617405 | biostudies-literature
UnknownNT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma.
Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage; however, the effect of systemic therapy on advanced HCC remains undetermined. Therefore, new treatment targets must be identified. We analyzed Gene Expression Omnibus datasets from two HCC patient cohorts and found that...
S-EPMC7206140 | biostudies-literature
UnknownHairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1.
B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is overexpressed in various cancer types. We found that Bmi-1 mRNA levels were elevated in nasopharyngeal carcinoma (NPC) cell lines. In immunohistochemical analyses, high Bmi-1 levels were observed in not only 5 of 38 n...
S-EPMC10258013 | biostudies-literature
UnknownEffect of Recombinant Human Granulocyte Colony-Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia: A Randomized Clinical Trial.

Importance

Lymphopenia is common and correlates with poor clinical outcomes in patients with coronavirus disease 2019 (COVID-19).

Objective

To determine whether a therapy that increases peripheral blood leukocyte and lymphocyte cell counts leads to clinical improvement in patients wit...
S-EPMC7489414 | biostudies-literature
ProteomicsTMT-based quantitative Proteomics Analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection
Highly pathogenic avian influenza virus (HPAIV) is a high morbidity-and mortality-associated disease that causes rapid systemic illness and death in susceptible animals. Lycorine, as the major component of Amaryllidaceae alkaloids, exhibits better protective effects against A/Chicken/Guangdong/178/2...
ORGANISM(S): Canis Lupus Familiaris 
PXD012936 |
UnknownAssociations between gestational diabetes mellitus and survival without bronchopulmonary dysplasia in very preterm infants: a multicentre cohort study.

Objective

To investigate whether gestational diabetes mellitus (GDM) was associated with survival without bronchopulmonary dysplasia (BPD) in very preterm infants (VPIs).

Design

Retrospective multicentre cohort study.

Setting

A total of 79 neonatal intensive care units across C...
S-EPMC12496082 | biostudies-literature
UnknownExtracting the femtometer structure of strange baryons using the vacuum polarization effect.
One of the fundamental goals of particle physics is to gain a microscopic understanding of the strong interaction. Electromagnetic form factors quantify the structure of hadrons in terms of charge and magnetization distributions. While the nucleon structure has been investigated extensively, data on...
S-EPMC11470094 | biostudies-literature
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