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ProteomicsFinding missing proteins from the epigenetically manipulated human cell with stringent quality criteria
There are three major epigenetic mechanisms, DNA methylation, histone modifications, and ncRNAs. The histone is a key player in epigenetics, and the acetylation and methylation are their most common post-translational modifications (PTMs). These histone modifications have important roles in transcri...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD002453 | Pride
Histone Chromosome-centric human proteome project Epigenetic Missing proteins 
TranscriptomicsAn Easy Operating Pathogen Microarray (EOPM) Platform for Rapid Screening of Vertebrate Pathogens
An Easy Operating Pathogen Microarray (EOPM) was designed to detect almost all known pathogens and related species based on their genomic sequences. For effective identification of pathogens from EOPM data, a statistical enrichment algorithm has been proposed and further implemented in a user-friend...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-45860 | biostudies-arrayexpress
MetabolomicsCharacteristics of myocardial structure and central carbon metabolism during the early and compensatory stages of cardiac hypertrophy
Cardiac hypertrophy is a classical forerunner of heart failure and myocardial structural and metabolic remodeling are closely associated with cardiac hypertrophy. We aim to investigate the characteristics of myocardial structure and central carbon metabolism of cardiac hypertrophy at different stage...
2024-08-23 | MTBLS10555 | MetaboLights
ProteomicsProteomic of control and FBL knockdown C4-2 cells
We employed a quantitative proteomics approach to compare the protein expression levels between control and FBL knockdown C4-2 cells, revealing expression levels of some proteins which have decreased mRNA half-life.
ORGANISM(S): Homo Sapiens 
2024-03-17 | PXD050701 |
ProteomicsA Hidden Human Proteome Encoded by the “Non-Coding” Genes
It has been a long debate whether the 98% “non-coding” fraction of human genome can encode functional proteins besides a “random noise” of translation. We used our established translatome sequencing (RNC-seq) to analyze human cells and found that up to 3330 long non-coding RNAs (lncRNAs) were bound ...
ORGANISM(S): Homo Sapiens 
2019-08-29 | PXD044056 |
ProteomicsMass Spectrometry analysis of potential proteins interacting with cyclin D1 mutants (T286A or T288A)
Co-IP assays and Proteomics were performed to identify potential E3 ligases interacted with both cyclin D1 T286A and cyclin D1 T288A.
ORGANISM(S): Homo Sapiens 
2024-05-17 | PXD052332 |
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
2025-10-14 | PXD069462 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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