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ProteomicsPre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis
Characterized by lethal iron accumulation and lipid peroxidation, ferroptosis plays critical roles in liver injury, especially caused by ischemia/reperfusion (I/R) of hepatic inflow occlusion during liver operation. However, the lack of effective and safe clinical precautionary measure is still the ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042083 | Pride
Interferon  dhx58  gpx4  m6a modification  ythdc2  ferroptosis 
UnknownNascent Genomic Evolution and Allopatric Speciation of Myroides profundi D25 in Its Transition from Land to Ocean.

Unlabelled

A large amount of bacterial biomass is transferred from land to ocean annually. Most transferred bacteria should not survive, but undoubtedly some do. It is unclear what mechanisms these bacteria use in order to survive and even thrive in a new marine environment. Myroides profund...
S-EPMC4725012 | biostudies-literature
UnknownA Novel Subfamily Esterase with a Homoserine Transacetylase-like Fold but No Transferase Activity.
Microbial esterases play important roles in deep-sea organic carbon degradation and cycling. Although they have similar catalytic triads and oxyanion holes, esterases are hydrolases and homoserine transacetylases (HTAs) are transferases. Because two HTA homologs were identified as acetyl esterases, ...
S-EPMC5394324 | biostudies-literature
UnknownShenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution.
Shenmai injection (SMI) is a Chinese patent-protected injection, which was mainly made of Red Ginseng and Radix Ophiopogonis and widely used for treating coronary heart disease and tumors by boosting Qi and nourishing Yin. In this study we examined whether SMI could produce direct synergetic effects...
S-EPMC5309759 | biostudies-literature
UnknownHamiltonian learning for 300 trapped ion qubits with long-range couplings.
Quantum simulators with hundreds of qubits and engineerable Hamiltonians have the potential to explore quantum many-body models that are intractable for classical computers. However, learning the simulated Hamiltonian, a prerequisite for any quantitative applications of a quantum simulator, remains ...
S-EPMC11777192 | biostudies-literature
UnknownInterferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.

Background

Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process i...
S-EPMC11017495 | biostudies-literature
UnknownKinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19: a descriptive study.

Background

To explore the kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19.

Methods

This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 design...
S-EPMC7652587 | biostudies-literature
UnknownCorrection: Limited Clinical Utility of Remote Ischemic Conditioning in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials.
[This corrects the article DOI: 10.1371/journal.pone.0170729.].
S-EPMC6138457 | biostudies-literature
UnknownLimited Clinical Utility of Remote Ischemic Conditioning in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials.

Objective

We conducted this meta-analysis of randomized controlled trials (RCTs) to investigate whether remote ischemic conditioning (RIC) could improve graft functions in kidney transplantation.

Methods

PubMed, Web of Science, and Cochrane Library were comprehensively searched to ide...
S-EPMC5271340 | biostudies-literature
UnknownPhosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth.
The proficiency of phyllosphere microbiomes in efficiently utilizing plant-provided nutrients is pivotal for their successful colonization of plants. The methylotrophic capabilities of Methylobacterium/Methylorubrum play a crucial role in this process. However, the precise mechanisms facilitating ef...
S-EPMC11252147 | biostudies-literature
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