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UnknownTo investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques.
Not available
S-EPMC10624676 | biostudies-literature
UnknownHigh Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by L-PRLR and S-PRLR.
Not available
S-EPMC10573079 | biostudies-literature
UnknownEffects of Electrolyte Multivitamins and Neomycin on Immunity and Intestinal Barrier Function in Transported Lambs.
Not available
S-EPMC10812564 | biostudies-literature
ProteomicsMulti-omics Analysis Shed Light on the Extracellular Role of PCMT1
Proteins are constantly damaged by intracellular and extracellular factors, particularly under stress conditions, leading to an accumulation of modified proteins like isoaspartate (isoD), which is linked to aging and various diseases. The repair enzyme PCMT1 (Protein-L-isoaspartate O-methyltransfera...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD058971 | Pride
Pcmt1  multi-omics  isoaspartate  extracellular  stress condition 
MetabolomicsMechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Mechanical force is critical for the development and remodeling of bone. Here we report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine (ADMA) via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 (Ddah1) expression in osteobla...

2021-11-23 | MTBLS3725 | MetaboLights
ProteomicsThe novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur
Type II Toxin-antitoxin (TA) systems are widely distributed in bacterial and archaeal genomes with diverse critical cellular functions such as defense against phages, biofilm formation, persistence and virulence. GCN5-related N -acetyltransferase (GNAT) toxin, with an acetyltransferase activity-dep...
ORGANISM(S): Pseudomonas Aeruginosa Pa14 
2022-05-05 | PXD033699 |
ProteomicsPhosphoproteomic and proteomic profiling in post-infarction chronic heart failure
We conducted a global quantitative phosphoproteomic and proteomic analysis of left ventricular (LV) tissues from post-infarction chronic heart failure rats. Phosphoproteomic and proteomic analysis can provide insights regarding molecular mechanisms underlying post-infarction chronic heart failure an...
ORGANISM(S): Rattus Norvegicus 
2023-06-09 | PXD042843 |
ProteomicsChilling-induced flower bud enlargement in Chimonanthus praecox
Proteome Analysis Reveals Insights into Chilling-induced flower bud enlargement in Chimonanthus praecox
ORGANISM(S): Chimonanthus Praecox 
2020-01-15 | PXD017101 |
ProteomicsThe proteomic navigator of human aging
Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of mult...
ORGANISM(S): Homo Sapiens 
2024-12-06 | PXD058638 |
ProteomicsQuantitative glycoproteomic, proteomic, and phosphoproteomic analysis of aged mouse ovary
In this work, we investigate the differences of site-specific N-glycosylation between young (2-month-old) and middle-aged (12-month-old) mouse ovarian tissues by integrating N-glycoproteomics and proteomic approaches with tandem mass tag (TMT) labeling.To identify signalling pathways associated with...
ORGANISM(S): Mus Musculus 
2024-09-14 | PXD056126 |
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