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ProteomicsRepairing of isoaspartyl residues by PCMT1 alleviates renal fibrosis through the repression of TGF-β1/TGFBR2/Smad signaling pathway
Protein L-isoaspartyl/D-aspartyl Methyltransferase (PCMT1) plays a pivotal role in repairing a spontaneous post-translational modification (PTM) of L-isoaspartyl residues resulted from asparagine deamidation or aspartate isomerization. This PTM is particularly important for extracellular matrix (ECM...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD047057 | Pride
Pcmt1 Tgf-β1-smad pathway Isoaspartyl residues Tgfbr2 Extracellular matrix Renal fibrosis 
ProteomicsMulti-omics Analysis Shed Light on the Extracellular Role of PCMT1
Proteins are constantly damaged by intracellular and extracellular factors, particularly under stress conditions, leading to an accumulation of modified proteins like isoaspartate (isoD), which is linked to aging and various diseases. The repair enzyme PCMT1 (Protein-L-isoaspartate O-methyltransfera...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD058971 | Pride
Pcmt1  multi-omics  isoaspartate  extracellular  stress condition 
GenomicsIsoDGR specific monoclonal antibody improves lung pathophysiology of PCMT1 knockout mice
IsoDGR specific monoclonal antibody improves lung pathophysiology of PCMT1 knockout mice
PRJNA931242 | ENA
ProteomicsPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can form spontaneously, an enzyme that regulates the formation of ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-05 | PXD061730 | Pride
Crbn Pcmt1 C-terminal cyclic imide Glul Ppa1 
TranscriptomicsIsoDGR specific monoclonal antibody improves lung pathophysiology of PCMT1 knockout mice
At present work we have used PCMT1-/- (premature aging) and PCMT1+/- (aged) as the animal model to studies the role of isoDGR in the ageing and age associated disease in the pulmonary system We performed gene expression profiling analysis using data obtained from RNA-seq of Lung of PCMT1+/+, PCMT1+/...
ORGANISM(S): Mus musculus 
2023-04-17 | GSE224434 | GEO
GenomicsRepairing of isoaspartyl residues by PCMT1 alleviates renal fibrosis through the repression of TGF-β1/TGFBR2/Smad signaling pathway
Repairing of isoaspartyl residues by PCMT1 alleviates renal fibrosis through the repression of TGF-β1/TGFBR2/Smad signaling pathway
PRJNA1043803 | ENA
TranscriptomicsRepairing of isoaspartyl residues by PCMT1 alleviates renal fibrosis through the repression of TGF-β1/TGFBR2/Smad signaling pathway
Protein L-isoaspartyl/D-aspartyl Methyltransferase (PCMT1) plays a pivotal role in repairing a spontaneous post-translational modification (PTM) of L-isoaspartyl residues resulted from asparagine deamidation or aspartate isomerization. This PTM is particularly important for extracellular matrix (ECM...
ORGANISM(S): Homo sapiens Mus musculus 
2024-01-01 | GSE248435 | GEO
GenomicsPCMT1–BCLAF1/TET1-Related Regulatory Networks Involved in Chromatin Accessibility Remodeling and Epitranscriptional Regulation in Triple-Negative Breast Cancer
A stable PCMT1 knockdown model was established in MDA‑MB‑231 cells, and the knockdown efficiency was verified by qRT‑PCR and Western blot. ATAC‑seq was employed to analyze genome‑wide chromatin accessibility changes between the sh‑PCMT1 and sh‑NC groups, and the results were integrated with previous...
ORGANISM(S): Homo sapiens 
2026-09-15 | GSE346467 | GEO
UnknownElevated expression of protein-L-isoaspartate O-methyltransferase-1 (PCMT1) in cervical cancer.
Not available
S-EPMC9459589 | biostudies-literature
GenomicsPCMT1–BCLAF1/TET1-Related Regulatory Networks Involved in Chromatin Accessibility Remodeling and Epitranscriptional Regulation in Triple-Negative Breast Cancer
PCMT1–BCLAF1/TET1-Related Regulatory Networks Involved in Chromatin Accessibility Remodeling and Epitranscriptional Regulation in Triple-Negative Breast Cancer
PRJNA1525596 | ENA
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