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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsComparative proteomics data of wild-type and hapB deletion strains under the background of A1160
Comparative proteomics data of wild-type and hapB deletion strains.
ORGANISM(S): Aspergillus Fumigatus Cea17 
PXD027699 |
ProteomicsThe proteomic changes in Pseudobagrus vachelli muscle and brain induced by hypoxia
The present NGST, TMT and Q-TOF MS platform should provide unprecedented resources to address such questions as to how hypoxic condition affects gene, miRNA, protein, and metabolite expression and changes the molecular pathways, and whether miRNAs participate in this process. For this purpose, we ch...
ORGANISM(S): Tachysurus Vachellii 
PXD020425 |
UnknownS1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome
Not available
S-SCDT-EMM-2021-14904 | biostudies-other
ProteomicsSynthetic lethal combinations targeting PLK1-CBX8-GPX4 axis with BRAF and EGFR inhibition in BRAF V600E colorectal cancer
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and run into a bottleneck in the current treatment strategies. To identify regulatory pathways independent of the MAPK pathway in BRAFV600E CRC, we performed CRISPR-Cas9 screening, and and find targeting glutathione peroxidase 4 (GP...
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058213 |
ProteomicsTranscriptomic and proteomic analysis reveals a core Atg9 interactome in the regulation of yeast macroautophagy
In Saccharomyces cerevisiae, Atg9 is an important AuTophaGy-related (Atg) protein, plays critical roles in regulating macroautophagy/autophagy, and physically interacts with hundreds of proteins. How Atg9 interacting partners are synergistically orchestrated in autophagy are unclear. Here, we conduc...
ORGANISM(S): Saccharomyces Cerevisiae 
2019-01-19 | PXD012458 |
ProteomicsA novel variant of Salmonella enterica serovar Typhimurium with a rough colony morphology and multidrug resistance
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of salmonellosis, with various multidrug-resistant pathovariants emerging. Here, we investigated a distinct rough colony variant with potentially enhanced environmental adaptation in China. Whole-genome sequencing of 2,212 Chi...
ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Lt2 
PXD047483 |
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