Sort   by:  
 Page size 
UnknownAchieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles.
Not available
S-EPMC9024546 | biostudies-literature
UnknownThe Association between Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Respiratory Tract Infections in Preschool Children: A Wuhan Cohort Study.
Not available
S-EPMC10674762 | biostudies-literature
MetabolomicsUltraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured...
2022-10-24 | MTBLS2111 | MetaboLights
ProteomicsTianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation Of Arginase-Ornithine Pathway
Background: Pulmonary Fibrosis (PF) is an interstitial lung disease of unknown etiology, characterized by excessive accumulation of extracellular matrix in the lungs, which disrupts the structure and gas exchange of the alveoli. There are only two approved therapies for PF, nintedanib (Nib) and pirf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024058 | Pride
Proteomics Pulmonary fibrosis Arginase-ornithine pathway Arginase Tianlongkechuanling 
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
ProteomicsExosomal Proteomics Reveals Fatty Acid Metabolism Linked to Gefitinib Resistance in Non-Small Cell Lung Cancer
Extracellular vesicles (EVs) serve as critical mediators of intercellular communication, facilitating drug resistance in tumor microenvironments by transferring bioactive components like proteins. Despite their potential role in non-small cell lung cancer (NSCLC), systematic investigations into exos...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068676 | Pride
Nsclc Proteomics Exosomes Gefitinib resistance Fatty acid metabolism 
MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsA Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC, functioning as a central node in a stre...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076640 | Pride
UnknownExpression Pattern of FT/TFL1 and miR156-Targeted SPL Genes Associated with Developmental Stages in Dendrobium catenatum.
Not available
S-EPMC6600168 | biostudies-literature
ProteomicsPersulfidation alters gene regulatory programs and promotes endothelial specification
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown. Here we discovered that during directed differentiation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD071015 | Pride
Sulfide supplementation Endothelial commitment Persulfidation Stem cells 
Sort   by:  
 Page size