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ProteomicsVec-STING LS-MS and US2 STING LS-MS
Since US2 causes STING to be degraded through ubiquitination, we aimed to find any ubiquitin enzymes that might be implicated in this action.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053353 | Pride
Sting Us2 
UnknownIntegrin αvβ1 facilitates ACE2-mediated entry of SARS-CoV-2.
Integrins have been suggested to be involved in SARS-CoV-2 infection, but the underlying mechanisms remain largely unclear. This study aimed to investigate how integrins facilitate the ACE2-mediated cellular entry of SARS-CoV-2. We first tested the susceptibility of a panel of human cell lines to SA...
S-EPMC10651773 | biostudies-literature
UnknownSingle-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients.

Objectives

Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequ...
S-EPMC8934393 | biostudies-literature
UnknownDexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation.
Intestinal ischemia/reperfusion injury (I/R) is a common yet challenging-to-treat condition, presenting a significant clinical challenge. This study aims to investigate the protective mechanisms of Dexmedetomidine (Dex) against I/R injury, with a particular focus on its role in regulating autophagy ...
S-EPMC11542338 | biostudies-literature
UnknownPIN1-mediated ROS production is involved in antagonism of N-acetyl-L-cysteine against arsenic-induced hepatotoxicity.
Arsenic, a widely existing environmental contaminant, is recognized to be toxic to multiple organs. Exposure to arsenic results in liver damage via excessive production of reactive oxidative species (ROS). PIN1 regulates the levels of ROS. N-acetyl-L-cysteine (NAC) is an ROS scavenger that protects ...
S-EPMC9424717 | biostudies-literature
UnknownCYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target.

Objective

It has been shown that the CYFIP2 (Cytoplasmic FMR1-interacting protein 2) gene is apoptosis p53-dependent and is associated with poor prognosis in malignant tumors such as gastric cancer and other and cervical cancer. However, the prognostic potential of CYFIP2 in pancreatic cance...
S-EPMC11685368 | biostudies-literature
Unknown8-Formylophiopogonanone B induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells.
Cancer is one of the leading causes of death in the world. It is very important to find drugs with high efficiency, low toxicity, and low side effects for the treatment of cancer. Flavonoids and their derivatives with broad biological functions have been recognized as anti-tumor chemicals. 8-Formylo...
S-EPMC8557691 | biostudies-literature
UnknownEpigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment.
Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various malignancies. However, the role of LDHB in modulating immune responses against hepatocellular carcinoma (HCC) remains largely unknown. Here, we found that down-re...
S-EPMC11091036 | biostudies-literature
ProteomicsDiffrential proteomic analysis of mature and immature follicle fluid in yak
The mature and immature FF samples were subjected to mass spectrometry with the isobaric tags for relative and absolute quantification (iTRAQ). The differential proteomics between mature and immature FF revealed their striking differences in the protein components and functions, which may improve ou...
ORGANISM(S): Bos Grunniens 
2021-04-15 | PXD025426 |
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