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TranscriptomicsDirect reprogramming of human fibroblasts to functional hepatocyte-like cells
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress
TranscriptomicsDeep sequencing identifies PD0325901 modulated microRNAs in the J1 mESCs
PD0325901 is involved in improving reprogramming efficiency during inducing pluripotent stem cells (iPSC) or maintain a blastocyst-like state in embryonic stem cells (ESC). However, the knowledge about this small molecule regulating miRNAs in ESC was limited. To understand the role of miRNAs during ...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67570 | biostudies-arrayexpress
TranscriptomicsIdentifying PD0325901-regulated genes in the J1 mESCs
It has been demonstrated that PD0325901 promotes self-renewal of mouse embryonic stem cells, however, the target genes of PD0325901 are not fully understood. To better understand the downstream target genes of PD0325901, we performed Microarray analyses to identify their downstream targets. The data...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67534 | biostudies-arrayexpress
UnknownCOVID-19 transmission driven by age-group mathematical model in Shijiazhuang City of China.
Not available
S-EPMC10495604 | biostudies-literature
TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
ProteomicsAnalysis of Macleaya cordata leave under lead treatment
The objectives of this study were to investigate response and tolerance of Macleaya cordata to lead（Pb）toxicity based on comparative analysis of proteome.
ORGANISM(S): Macleaya Cordata 
2022-11-14 | PXD038143 |
UnknownTowards precision medicine based on a continuous deep learning optimization and ensemble approach.
Not available
S-EPMC9898519 | biostudies-literature
ProteomicsProteomic analysis of Macleaya cordata leaf under excess zinc
The objectives of this study were to investigate response and tolerance of Macleaya cordata to excess zinc based on comparative analysis of proteome.
ORGANISM(S): Macleaya Cordata 
2022-11-21 | PXD038219 |
ProteomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity
The programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingo...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD075012 |
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