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ProteomicsQuantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Metabolic fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, with steatosis as the underlying pathology. At the same time, MAFLD is also a high-risk factor for the development of metabolic diseases. Shenling Baizhu powder (SLP) is a traditional Chinese herbal for...
ORGANISM(S): Rattus Norvegicus 
PXD042049 |
ProteomicsMonitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts
Master transcription factor (mTF) has been recognized as topmost regulatory hierarchy in cell fate determination. However, the direct transcriptional targets of mTFs, and how the interplay between these transcriptional targets and their associated RNA-binding proteins (RBPs) orchestrate the realisat...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-28 | PXD043911 | Pride
Mouse Mesc 
ProteomicsFLAG-TCF21 interactome in HCT116 and TPCs by IP-MS
This project presents the proteomic profiling of protein complexes associated with the transcription factor TCF21, achieved through affinity purification coupled with mass spectrometry (AP-MS). The study aimed to comprehensively map the TCF21 interactome in two distinct cellular models: the human co...
ORGANISM(S): Homo Sapiens 
2025-12-12 | PXD071976 |
ProteomicsProteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis
Aflatoxin B1 (AFB1) is extremely carcinogenic and can cause liver cancer in humans and animals with continued ingestion. As a natural compound, curcumin (Cur) exhibits excellent anti-inflammatory, and anti-cancer properties with few side effects. In this study, a total of 60 male mice (6-week-olds, ...
ORGANISM(S): Mus Musculus 
PXD042376 |
ProteomicsEffects of ShosTA system on E.coli
To elucidate that ShosTA exerts an anti-phage function, we further explored the interacting proteins of ShosA. IP-MS/MS analysis reveals in vivo interactions between ShosA and some recombination-associated proteins. FLAG-tagged ShosA in the context of the full ShosTA system or FLAG-tag alone are use...
ORGANISM(S): Escherichia Coli 
PXD056215 |
ProteomicsExploration of the antioxidant effect of spermidine on the ovary and screening and identification of differentially expressed proteins
Spermidine is a naturally occurring polyamine compound that has many biological functions, such as inducing autophagy and anti-inflammatory and anti-aging effects. In this study, ICR mice were fed exogenous spermidine drinking water for three months to explore the regulation of ovarian function by s...
ORGANISM(S): Mus Musculus 
2022-12-12 | PXD038755 |
TranscriptomicsMet synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (aCGH data).
Transcriptional profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre. Two-color common reference design. Samples consist of 4 normal tissues, 8 MMTV-Met tumors, 10 MMTV-Met;Trp53fl/+;Cre tumors, and 8 Trp53...
ORGANISM(S): Mus musculus 
2013-03-04 | E-GEOD-41632 | biostudies-arrayexpress
TranscriptomicsMet synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (miRNA expression data).
miRNA profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre. One-color design. Samples consist of 2 normal tissues, 7 MMTV-Met tumors, 8 MMTV-Met;Trp53fl/+;Cre tumors, and 8 Trp53;Cre tumors.
ORGANISM(S): Mus musculus 
2013-03-04 | E-GEOD-41723 | biostudies-arrayexpress
TranscriptomicsMet synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (mRNA expression data).
Transcriptional profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre. Two-color common reference design. Samples consist of 11 normal tissues, 8 MMTV-Met tumors, 14 MMTV-Met;Trp53fl/+;Cre tumors, and 8 Trp5...
ORGANISM(S): Mus musculus 
2013-03-04 | E-GEOD-41601 | biostudies-arrayexpress
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