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TranscriptomicsReal-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1
Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqManM-BM-. Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2. qPCR miRNA expression profiling.
ORGANISM(S): Homo sapiens 
2012-08-11 | E-GEOD-40019 | biostudies-arrayexpress
UnknownImpact of Variability in Portal Venous Phase Acquisition Timing in Tumor Density Measurement and Treatment Response Assessment: Metastatic Colorectal Cancer as a Paradigm.

Purpose

New response patterns to anticancer drugs have led tumor size-based response criteria to shift to also include density measurements. Choi criteria, for instance, categorize antiangiogenic therapy response as a decrease in tumor density > 15% at the portal venous phase (PVP). We studi...
S-EPMC6874047 | biostudies-literature
ProteomicsPhosphoproteomics reveal that phosphorylation of MTDH by CDK5 inhibits protein synthesis in microglia
Our findings identified 335 phosphorylation sites on 234 proteins as potential CDK5 substrates in microglia based on the reported sequence motif
ORGANISM(S): Mus Musculus 
2024-03-08 | PXD050465 |
UnknownMachine learning integration of multi-modal analytical data for distinguishing abnormal botanical drugs and its application in Guhong injection.

Background

Determination of batch-to-batch consistency of botanical drugs (BDs) has long been the bottleneck in quality evaluation primarily due to the chemical diversity inherent in BDs. This diversity presents an obstacle to achieving comprehensive standardization for BDs. Basically, a sin...
S-EPMC10759515 | biostudies-literature
TranscriptomicsSUDHL-4 cells: suspension vs. co-cultured with HK cells
We first performed miRNA analysis on SU-4 cells in suspension, and after 24 and 48 h of HK co-culture. To ensure that no HK cell contamination occurred, SU-4 cells in suspension and after co-culture were purified by CD19-positive magnetic selection, followed by total RNA isolation. Two-condition exp...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-49253 | biostudies-arrayexpress
UnknownA viral protein disrupts rice cell wall integrity and modulates interactions with viruses and insects.
The plant cell wall provides structural support and serves as a barrier against pathogen invasion. Rice grassy stunt virus (RGSV) infection suppresses genes involved in cell wall biosynthesis, but the underlying mechanism remains unclear. To further investigate this phenomenon, we generated transgen...
S-EPMC12921124 | biostudies-literature
UnknownChina National Medical Products Administration approval summary: anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy.

Background

On May 8, 2018, the China National Medical Products Administration (NMPA) approved anlotinib, an orally administered anti-angiogenesis inhibitor, for the treatment of patients with advanced non-small cell lung cancer (NSCLC) who have progressed after treatment with two or more lin...
S-EPMC6585030 | biostudies-literature
Proteomicsimmunoprecipitation-mass spectrometry related to rice stripe virus SP
immunoprecipitation-mass spectrometry related to rice stripe virus SP
ORGANISM(S): Oryza Sativa 
PXD063713 |
ProteomicsFecal protein changes in different colorectal diseases
We examined fecal proteins from normal subjects (n=6), patients with inflammatory bowel disease (n=8), patients with colorectal adenoma (n=8), and patients with colorectal cancer (n=14) in the hope of identifying novel fecal protein markers that could be used to identify colorectal diseases.
ORGANISM(S): Homo Sapiens 
2022-12-22 | PXD039089 |
MetabolomicsMetabolomics Investigation of Dietary Effects on Flesh Quality in Grass Carp (Ctenopharyngodon idellus)

BACKGROUND: The ultra-high density intensive farming model of grass carp (Ctenopharyngodon idellus) may elicit inhibite the growth, decline flesh quality and disease resistance of fish. The quality degradation and excessive fat accumulation in cultured C. idellus have long been a...

2018-08-17 | MTBLS673 | MetaboLights
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