Proteome and N-glycoproteome in human plasma were analyzed and compared between B4GALT1 WT and N352S genotypes. The results showed that N352S significantly decreased galactosylation for a wide range of proteins, especially apoB and fibrinogen, which may be associated with the decreased LDL-c level o...
Photoaging is cumulative damage that is caused by chronic, repeated solar radiation exposure to skin. Its molecular mechanisms are poorly understood at the level of global gene expression.This study set out to uncover genes and functional modules involved in photoaging at the level of transcription,...
Rabies virus (RABV) infection led to alteration of microRNA expression in NA and microglia. A sixteen-chip study was performed using total RNA isolated from NA and microglia infected with rabies virus CVS-11 (Challenge virus standard) or mock infected as a control. RNA was isolated from microglia at...
Host-virus interaction was analyzed at microRNA expression level. The hypothesis tested in the present study was that rabies virus (RABV) infection affects the microRNA expression in brains of mice and RABV with different virulence induce distinct microRNA expression pattern in host. Results provide...
The hypothesis tested in the present study was that rabies virus (RABV) infection affects the gene expression in microglial cells. Results provide important information that RABV infection led to alteration of gene expression in microglia. A twelve-chip study was performed using total RNA isolated f...
Host-virus interaction was analyzed at gene expression level. The hypothesis tested in the present study was that rabies virus (RABV) infection affects the gene expression in brains of mice and RAB with different virulence induce distinct expression pattern in host. Results provide important informa...
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
A total of 30 days of exposure to cigarette smoke (CS) or indoor air was given to 8- 23 week-old female C57BL/6 mice, then proteomics analyses were used to determine the 24 impact of CS on ovarian reserve.
Sanfilippo syndrome type B (MPS III B) is an autosomal recessive, neurodegenerative disease of children, characterized by profound mental retardation and dementia. The primary cause is mutation in the NAGLU gene, resulting in deficiency of N-acetylglucosaminidase and lysosomal accumulation of hepara...
