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MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
TranscriptomicsCharacterization of microRNAs expression during maize seed development
In this study, two small RNA libraries were sequenced, and a total reads of 9,705,761 and 9,005,563 were generated from developing seeds and growing leaves, respectively. Further analysis identified 125 known miRNAs in seeds and 127 known miRNAs in leaves. 54 novel miRNAs were identified and they we...
ORGANISM(S): Zea mays 
2012-08-07 | E-GEOD-37551 | biostudies-arrayexpress
TranscriptomicsmiRNA Expression data from maize young leaf and developing seed
miRNAs of at least 2 times expression level higher in seeds were all from the miR319, miR171 and miR166 family. In leaves, most up-regulated miRNAs included miR399a/c/d/e, miR408, miR159c/d, miR156k/j, miR160a/b/c/d/e and miR164a/b/c/d We intend to identify the up-regulated miRNAs in maize seed and ...
ORGANISM(S): Zea mays 
2012-08-06 | E-GEOD-37322 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
MetabolomicsIntegrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients

Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli...

2026-03-19 | MTBLS14087 | MetaboLights
Proteomicsgp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination
To identify the target protein of gp78 that regulates KAP1 phosphorylation, we conducted an analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS), which identified several putative target proteins.
ORGANISM(S): Homo Sapiens 
PXD054846 |
ProteomicsKLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs ...
ORGANISM(S): Homo Sapiens 
2022-11-09 | PXD038057 |
ProteomicsBacterial Protoplast-Derived Nanovesicles Carrying CRISPR Cas9 Tools Efficiently Re-educate Tumor-Associated Macrophages for Cancer Immunotherapy
we developed an in vivo CRISPR-Cas9 genome editing system that targets tumor-associated macrophages (TAMs) via bacterial protoplast-derived nanovesicles (NVs) decorated with a pH-responsive PEG conjugated polymer and galactosamine-conjugated ligand
ORGANISM(S): Escherichia Coli Bl21(de3) 
PXD045507 |
ProteomicsModulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
Modulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
ORGANISM(S): Macaca Fascicularis Fascicularis 
2023-02-10 | PXD040009 |
ProteomicsGut microbiota production of N,N,N-trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy in diet-induced obesity
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
ORGANISM(S): Mus Musculus 
PXD028230 |
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