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ProteomicsAn anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
The emergence of new highly pathogenic and drug-resistant influenza strains urges the development of novel therapeutics for influenza A virus (IAV). Here, we report the discovery of an anti-IAV microbial metabolite called APL-16-5 that was originally isolated from the plant endophytic fungus Aspergi...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031993 | Pride
Influenza a virus  proteolysis-targeting chimeras  trim25  phenalenone derivatives  microbial metabolites  antiviral drug 
UnknownTeicoplanin derivatives block spike protein mediated viral entry as pan-SARS-CoV-2 inhibitors.
Not available
S-EPMC9808420 | biostudies-literature
UnknownAn integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers.
Not available
S-EPMC6341564 | biostudies-literature
UnknownRepurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLpro.
Not available
S-EPMC9499987 | biostudies-literature
Proteomicsimmunoprecipitation coupled with a mass spectrometry (MS) approach to identify cellular proteins associated with MOV10
To understand the detailed mechanism underlying MOV10-mediated restriction of LINE-1 retrotransposition, we first performed immunoprecipitation coupled with a mass spectrometry (MS) approach to identify cellular proteins associated with MOV10.
ORGANISM(S): Homo sapiens (Human) 
2023-08-30 | PXD041814 | Pride
Mass，mov10 Ip 
UnknownDiscovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors.
Not available
S-EPMC8191315 | biostudies-literature
Unknown2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors.
Not available
S-EPMC8600920 | biostudies-literature
UnknownA cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase.
Not available
S-EPMC8059291 | biostudies-literature
UnknownThe CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR.
Not available
S-EPMC8379306 | biostudies-literature
UnknownAuthor Correction: An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA.
Not available
S-EPMC10290065 | biostudies-literature
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