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ProteomicsAn integrated MS data processing strategy for fast identification, in-depth and reproducible quantification of protein O-glycosylation in large cohorts of human urine samples
Protein O-glycosylation has long been recognized to be closely associated with many diseases, particularly with tumor proliferation, invasion and metastasis. The ability to efficiently profile the variation of O-glycosylation in large-scale clinical samples provides an important approach for the devel...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD015987 | Pride
O-glycopeptide  urine  sialic acid 
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
ProteomicsAn Orthogonal Extraction Workflow for High-Depth Plasma Proteomics with Metabolomic Compatibility from Low Microliter-Scale Samples
Herein, we report an orthogonal extraction workflow that achieves enhanced proteomic profiling depth while preserving metabolomic compatibility from a mere 10 µL of plasma. We demonstrate that a ternary solvent mixture (TSM) of methanol, acetonitrile, and acetone exhibits distinct chemical orthogona...
ORGANISM(S): Homo Sapiens 
2026-02-03 | PXD073964 |
ProteomicsProteome-wide identifying site non-specific cross-linking peptides with SpotLink
We developed SpotLink to identify site non-specific cross-links from the proteome scale. Here described the Abeta dataset and the HeLa dataset to evaluate SpotLink.
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD030274 | Pride
Spotlink Cross-linking Cx-ms Site non-specific Cl-ms Proteome 
ProteomicsTandem Enrichment and Simultaneous Profeling
Tandem Enrichment and Simultaneous Profeling of N-glycopeptides and phosphopeptides
ORGANISM(S): Homo Sapiens 
2022-04-18 | PXD033282 |
UnknownNursing Students From China and the United States: Learning Together Through Virtual Simulation.
Not available
S-EPMC9050818 | biostudies-literature
ProteomicsCircular RNA circBNC2 regulates epithelial cell G2-M arrest to prevent fibrotic maladaptive repair
Epithelial cells arrested in G2/M phase of the cell cycle after injury is a key checkpoint for determining the wound-healing to either normal cell proliferation or fibrosis. The mechanism that regulates the fibrogenic response after injury is not well understood. Here, we identified a kidney- and li...
ORGANISM(S): Homo Sapiens 
2022-04-18 | PXD033284 |
ProteomicsSpin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate c...
ORGANISM(S): Mus Musculus 
2026-04-08 | PXD076742 |
ProteomicsComprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes
A comprehensive proteomic and genomic analysis of 438 trace tumor samples from 156 duodenal cancers, covering all 8 major histopathology stages of 2 major and 5 rare subtypes in 23 substages via pathological dissection.
ORGANISM(S): Homo Sapiens 
2022-12-16 | PXD038867 |
ProteomicsIntegrative Proteogenomic Characterization of Early Esophageal Cancer
A comprehensive proteogenomic analysis of 786 trace-tumor-samples from 154 esophageal cancers, covering all 9 major histopathology stages and 22 substages via pathological dissection.
ORGANISM(S): Homo Sapiens 
2022-12-20 | PXD038961 |
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