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ProteomicsDefining proximity proteomics of Histone modifications by antibody-mediated protein A-APEX2 labeling
Proximity labeling catalyzed by promiscuous enzymes, such as APEX2, has emerged as a powerful approach to characterize multiprotein complexes and protein–protein interactions. However, current methods depend on the expression of exogenous fusion proteins and cannot be applied to identify proteins su...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-12 | PXD028063 | Pride
Proximity labeling  post-translationally  amapex  modified histones 
ProteomicsTumor temporal proteome profiling reveals the immunological triple offensive induced by synthetic anti-cancer Salmonella
The engineered “obligate” anaerobic Salmonella typhimurium strain YB1 shows a prominent ability to repress tumor growth and metastasis, which has great potential as a novel cancer immunotherapy. However, the antitumor mechanism of YB1 remains unelucidated. To resolve the proteome dynamics induced by...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-13 | PXD026288 | Pride
Quantitative proteomics Tumor specific t cell Cancer immunotherapy Blood coagulation M1 macrophage Engineered salmonella 
TranscriptomicsNucleosome positioning changes during human embryonic stem cell differentiation.
Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human embryonic stem cells (hESCs) transition to nascent mesoderm and...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-45877 | biostudies-arrayexpress
MetabolomicsChromosome‐level genome of Camellia lanceoleosa provides a valuable resource for understanding genome evolution and self‐incompatibility

The section Oleifera (Theaceae) has attracted attention for the high levels of unsaturated fatty acids found in its seeds. Here, we report the chromosome-scale genome of the sect. Oleifera using diploid wild Camellia lanceoleosa with a final size of 3.00 Gb and an N50 s...

2022-07-14 | MTBLS3769 | MetaboLights
TranscriptomicsMicroarray analysis of the impact of high glucose on gene expression in cytotoxic T lymphocytes
This dataset of microarray analysis was designed to examine the impact of high glucose-culture on transcriptomics/gene expression in primary human CD8+ T cells. Primary human CD8+ T cells were isolated from peripheral blood mononulcear cells of healthy donors and stimulated with anti-CD3/anti-CD28 a...
ORGANISM(S): Homo sapiens 
2022-02-20 | E-MTAB-11441 | biostudies-arrayexpress
ProteomicsIdentification of circEZH2_005-interacting proteins by mass spectrometry
liquid chromatography tandem mass spectrometry is used to identificate of the circEZH2_005-Interacting protein pulled down by circEZH2_005 junction probe with protein extracts from Intestinal crypt cells.
ORGANISM(S): Mus Musculus 
2023-03-17 | PXD040925 |
ProteomicsCharacterization of kidney-specific and site-specific N-glycosylation signatures of isolated uromodulin from human urine
Uromodulin (Umod, Tamm–Horsfall protein), as the most abundant urinary N-glycoprotein exclusively produced by the kidney, can form filaments to antagonize the adhesion of uropathogens. However, the kidney-specific and site-specific N-glycosylation signatures of this glycoprotein remain poorly unders...
ORGANISM(S): Homo Sapiens 
PXD041640 |
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