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ProteomicsATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.
This dataset contains label-free immunoprecipitation mass spectrometry (IP-MS) data to identify interacting partners of target proteins in human cell lines. Two sample groups (OMM2.3-input, OMM2.3-IP) were generated via co-immunoprecipitation with anti-HBO1 antibody. All LC-MS/MS proteomic detection...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD081136 | Pride
Atr Histone acetyltransferase Phosphorylation Hbo1 Replication stress 
ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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