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MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
ProteomicsComposition and RNA binding specificity of metazoan RNase MRP
Mechanistic studies have revealed ribonuclease (RNase) MRP, a conserved RNA-based enzyme, is crucial for the maturation of ribosomal RNA in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain unknown. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD061658 | Pride
Nepro Ribonuclease (rnase) mrp C18orf21 Ip-ms 
UnknownComparison of prognostic prediction models for rectal gastrointestinal stromal tumor.
Not available
S-EPMC7343501 | biostudies-literature
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
Proteomicsproteomic content of HUVEC-Exos in HP and NP conditions
HUVEC were treated with 3 mM (pH=7.4) as the high concentration of phosphorus (HP) and normal phosphorus (NP) for exosomes concentration. The HUVEC-Exos samples (HP: 3 samples, NP: 3 samples) were processed for label-free-based quantitative proteomic analysis using high-performance liquid chromatogr...
ORGANISM(S): Homo Sapiens 
2022-09-21 | PXD036925 |
MetabolomicsParabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces ...
2023-11-01 | MTBLS7943 | MetaboLights
ProteomicsIdentification of key elements and pathways regulated by Yiqi Sanjie formula against colorectal cancer based on integrative analyses
The Yiqi Sanjie (YQSJ) formula has been proved to be clinically useful for stage III colorectal cancer (CRC) patients. However, the exact anti-tumor mechanisms of YQSJ and its main active component peiminine remain incompletely understood. This study aimed to comprehensively explore the characteriza...
ORGANISM(S): Homo Sapiens 
2022-09-30 | PXD037110 |
ProteomicsElevated N-glycosylation of Membrane Proteins Contributes to the Cisplatin Resistance of Non-small-cell Lung Cancer Cells
Chemoresistance remains to be the major restriction on the clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with the growth, invasion, metastasis, and resistance to chemotherapy of cancer cells. Comprehensive study on the role of protein glycosylation in th...
ORGANISM(S): Homo Sapiens 
PXD028691 |
GenomicsGonadal DNA methylomes of half-smooth tongue sole Cynoglossus semilaevis
Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa, and in some species co-occurs with genetic sex determination (GSD) mechanisms. Although epigenetic regulation in response to environmental effects has long been proposed to be associated with ESD, a systemic ...
ORGANISM(S): Cynoglossus semilaevis 
2014-01-23 | E-GEOD-41129 | biostudies-arrayexpress
ProteomicsQuartet Protein Reference Materials for Multi-platform Assessment of Label-free Proteomics
We developed the Quartet as a bulk of proteome reference materials with built-in truth, and distributed the same aliquots to 15 laboratories in six cities of China with nine conventional LC-MS/MS platforms. Relative protein abundances from over 12,000 proteins on 816 MS files were obtained and compa...
ORGANISM(S): Homo Sapiens 
PXD043262 |
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