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MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
ProteomicsApplication of integrated omics in aseptic loosening of prostheses after hip replacement
Aseptic loosening (AL) of artificial hip joints is the most common complication following hip replacement surgery. In the present study, second-generation high-throughput sequencing and mass spectrometry techniques were used to detect differentially expressed genes, proteins and metabolites in sampl...
ORGANISM(S): Homo Sapiens 
2024-12-14 | PXD058886 |
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
ProteomicsProteomic analysis of EVs from human UCMSC
Proteomic analysis of EVs from human Umbilical Cord Mesenchymal Stem Cells
ORGANISM(S): Homo Sapiens 
2024-09-02 | PXD055465 |
ProteomicsAmelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-06-15 | PXD053163 |
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsAcellular Nerve Perineurium Repairs Peripheral Nerve Injuries in a Rat Model via ECM-Mediated Barrier and Optimization of the Regenerative Microenvironment: Raw date of the proteomics analysis in this study
The project IPX0014571000 in iProX as an example dataset, which is composed of the raw data and analysis results of the study paper"Acellular Nerve Perineurium Repairs Peripheral Nerve Injuries in a Rat Model via ECM-Mediated Barrier and Optimization of the Regenerative Microenvironment".
ORGANISM(S): Rattus Norvegicus Canis Lupus Familiaris 
2025-12-17 | PXD071986 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055730 |
ProteomicsMulti-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have acceptab...
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061119 |
ProteomicsData Submission: Proteomic Identification of Proteins Interacting with CircRNA
This project submits the proteomic dataset of proteins interacting with the specific circular RNA Circ-018468, identified by ChIRP-MS (Chromatin Isolation by RNA Purification coupled with Mass Spectrometry). The experiment was performed using cell samples, with a negative control (non-specific probe...
ORGANISM(S): Mus Musculus 
2025-12-23 | PXD072338 |
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