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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsTumor-derived L-arginine acts as a metabolic checkpoint to sustain CAR T cell anti-tumor memory

Metabolic competition within the tumor microenvironment (TME) severely impairs the efficacy and persistence of chimeric antigen receptor (CAR) T cells in solid tumors. While targeting tumor metabolism is a promising therapeutic avenue, its precise implementation remains a challenge. Here, we disc...

2026-10-23 | MTBLS14035 | MetaboLights
TranscriptomicsEgr2-dependent expression in T cell anergy
T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46242 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Bone Marrow Macrophages and Spleenic Macrophages Transcriptomes in mouse T cell acute lymphoblastic leukemia
The goals of this study aim to reveal functional and phenotypic diversity of leukemia-associated macrophages in response to the microenvironmental cues in mouse T cell acute lymphoblastic leukemia Compare Transcriptomes of macrophages in T cell acute leukemia which are suggested as leukemia-associat...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-63751 | biostudies-arrayexpress
TranscriptomicsCITE-seq of human blood CD8+ T cells
The purpose of the experiment was to investigate the differentiation state gradient among antigen-experienced CD8+ T cells in healthy human blood. This was a sub-goal within a larger experiment, which aimed to investigate the clonal relationship between CD8+ T cells in blood and skin of matched dono...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-13034 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients.
Single-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional properties of these individual cells, coupled with the assembled T cell receptor (TCR) sequences, were used to delineat...
EGAS00001002072 | EGA
GenomicsGenome-wide maps of EGR2 transcription factor binding sites in T cell anergy
We report the application of sequencing technology for mapping the EGR2 transcriptional program in T cell anergy Examination of Egr2 genomic binding sites in T cells following overnight treatment with immobilized anti-CD3 mAb (1ug/ml)
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46241 | biostudies-arrayexpress
TranscriptomicsRole of EGR2 transcription factor in T cell anergy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46243 | biostudies-arrayexpress
TranscriptomicsSingle cell CITE-seq and VDJ sequencing of CD8+ central memory blood T cells (TCM) and their in-vivo matured tissue-resident memory-like T cells (TRM)
The aim of the experiment was to understand the clonal relationship between CD8+ central memory blood T cells (TCM) and the in-vivo matured TCM tissue-resident memory-like T cells (TRM) on day 14. TCM were FACS sorted from human PBMCs (n=5). Half of the cells were processed on day 1 and half of the ...
ORGANISM(S): Homo sapiens 
2023-06-12 | E-MTAB-12840 | biostudies-arrayexpress
TranscriptomicsEvaluation of effect of PTEN gene deletion in mouse CD4+ Th1 clones after stimulation
PTEN is thought to play a critical role in T cell activation by negatively regulating the PI3K signaling pathway important for cellular activation, growth, and proliferation. T cells from mice in which PTEN was conditionally deleted in the thymus were reported to display CD28-independent IL-2 produ...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43936 | biostudies-arrayexpress
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