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ProteomicsDiscovery of a small molecule inhibitor of the UBE2F-CRL5 axis that induces apoptosis and G2/M arrest and confers radiosensitization
Protein neddylation modification is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme and an E3 ligase. In various types of human cancers, the neddylation pathway was abnormally activated. Our previous study validated that neddylation E2 UBE2F is a promising lung cance...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD036191 | Pride
Ube2f  neddylation  apoptosis  cell cycle arrest  small molecule inhibitor 
ProteomicsSpatial phosphoproteomics reveals phosphorylation features in liver cirrhosis
Liver cirrhosis (LC) is the end stage of chronic liver disease, characterized by pseudolobule formation and extensive fibrosis, with unclear regional dynamics of protein phosphorylation. This study used spatial phosphoproteomics combined with bioinformatics to analyze phosphorylation patterns in LC ...
ORGANISM(S): Homo Sapiens 
2025-11-21 | PXD071108 |
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