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UnknownBasement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.
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S-EPMC12637266 | biostudies-literature
MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
ProteomicsProteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling
Recently, numerous efforts have been devoted to identifying drug targets and binding sites in complex proteomes, which is of great importance in modern drug discovery. In this study, we developed a robust lysine reactivity profiling method to systematically study drug-binding targets and binding sit...
ORGANISM(S): Homo Sapiens 
2023-09-28 | PXD045749 |
ProteomicsProteomics analysing the exosomes extratced from the BALF of the E.coli or LPS induced acute lung injury (ALI) model
We established E.coli and LPS induced ALI murine model. Then, at 24 hours, the exosome from the BALF were extracted by the Size Exclusion Chromatography (SEC) method and analyzed by quantitive mass spectrometry
ORGANISM(S): Mus Musculus 
2023-10-17 | PXD046185 |
ProteomicsThe RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
We established an APEX proximity labeling strategy in coupled with mass spectrometry to identify interacting proteins of RNF214. In this approach, we first fused an engineered ascorbate peroxidase (APEX2) to either N-terminus or C-terminus of RNF214, expressed these two fusion proteins in HLF, an HC...
ORGANISM(S): Homo Sapiens 
2024-02-18 | PXD049453 |
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