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ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080724 | MassIVE
ProteomicsCoupled protein synthesis and ribosome-guided piRNA processing on mRNAs
PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. Previously, we showed that ribosomes guide the biogenesis of piRNAs from long non-coding RNAs (lncRNAs) after translating the short open reading frames (ORFs) near their 5′ cap. It remained unclear, how...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-17 | PXD027489 | Pride
Mouse Protein synthesis Pirna Mrna Testis Lc-ms/ms 
Proteomicsproteomics to analyze the growth-promoting effect of a potential new plant growth regulator GZU001 on maize (Zea mays L.) roots
Plant growth regulators are the chemical substances that regulate growth and development in plants. The use of plant growth regulators on crops can adjust the balance of hormones and influence plant growth, thereby increasing crop yield and/or improving crop quality. Fubianliusuoyoumi (GZU001), a ne...
ORGANISM(S): Zea Mays 
PXD026760 |
ProteomicsA Novel Classifier Based on Urinary Proteomics for Distinguishing between Benign and Malignant Ovarian Tumors
Preoperative differentiation of benign and malignant tumor types is critical for providing individualized treatment interventions to improve prognosis of patients with ovarian cancer. High-throughput proteomics analysis of urine samples was performed to identify reliable and non-invasive biomarkers ...
ORGANISM(S): Homo Sapiens 
PXD027695 |
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
ProteomicsComputational Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage and Applications to 15 Tumors
a computational strategy for the size optimization of DIA spectral library, which refines a comprehensive library by a prior analysis of DIA data of a particular tissue type
ORGANISM(S): Homo Sapiens 
2021-12-27 | PXD030648 |
ProteomicsDPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins
we generated DPHL v2 from 1608 DDA-MS data acquired using Orbitrap mass spectrometers. The data included 586 DDA-MS newly acquired from 17 tissue types, while 1022 files were derived from DPHL v1. DPHL v2 thus comprises data from 24 sample types, including several cancer types . We generated four va...
ORGANISM(S): Homo Sapiens 
2023-01-18 | PXD039313 |
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