A metagenomic binning analysis was performed on fecal samples from 50 healthy calves and 50 diarrheic calves to comprehensively investigate the association between microbial dysbiosis and calf diarrhea. By integrating shotgun metagenomics, untargeted metabolomics, targeted bile acid metabolomics,...

Tripterygium wilfordii is a vine used in Traditional Chinese Medicine (TCM) from the family Celastraceae. The active ingredient celastrol is a friedelane-type pentacyclic triterpenoid, with a putative role as an anti-tumor, immunosuppression, and obesity agent. Here we reported a referen...

Analysis of the molecular etiologies of severe combined immunodeficiency (SCID) has led to important insights into the control of immune cell development. Most cases of SCID result from either X-linked or autosomal recessive inheritance of mutations in a known causative gene. However, in some cas...