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TranscriptomicsSclerotinia infected vs Mock infected controls in B. napus Westar and Zhong You 821
This SuperSeries is composed of the following subset Series: GSE13254: Sclerotinia infected vs Mock infected controls in B. napus (Westar) GSE13256: Zhong You 821 Sclerotinia infected vs Mock infected controls in B. napus (Zhong You 821) The fungal pathogen Sclerotinia sclerotiorum infects a broad ...
ORGANISM(S): Brassica napus 
2009-01-31 | E-GEOD-13262 | biostudies-arrayexpress
TranscriptomicsZhong You 821 Sclerotinia infected vs Mock infected controls in B. napus (Zhong You 821)
The fungal pathogen Sclerotinia sclerotiorum infects a broad range of dicotyledonous plant species and is the causative agent of stem rot in Brassica napus. To elucidate the mechanisms underlying the defense response, we studied the patterns of gene expression in a partially resistant variety of Zho...
ORGANISM(S): Brassica napus 
2010-05-06 | E-GEOD-13256 | biostudies-arrayexpress
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
TranscriptomicsDepletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos
Foxk proteins are transcriptional regulators implicated in key biological processes such as glycolysis, autophagy and cell cycle regulation, among others. Here we employ targeted morpholino knockdown to deplete Foxk1, Fokx2, and Foxk2-1 proteins in developing zebrafish embryos. We demonstrate that t...
ORGANISM(S): Danio rerio 
2020-12-01 | E-MTAB-9777 | biostudies-arrayexpress
TranscriptomicsCell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible interblastomere differences among ten 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-57249 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of endocycling cells vs mitotic cells
In this study we used expression microarrays as an entry point to gain further insights into the differences between endocycling cells and mitotic cycling in tissues of the Drosophila larva. Gene expression analyses were performed on tissues hand dissected from yw67c2 early 3rd instar larval tissues...
ORGANISM(S): Drosophila melanogaster 
2010-08-12 | E-GEOD-19029 | biostudies-arrayexpress
TranscriptomicsGenome-wide miRNA profile of MCF7 cells overexpressing wild-type and mutant miR-222
MCF7 cells were infected with retrovirus to overexpress wild-type and mutant miR-222 Measure miRNA expression level in MCF7 cells after overexpressing wild-type and mutant miR-222
ORGANISM(S): Homo sapiens 
2015-02-05 | E-GEOD-64363 | biostudies-arrayexpress
TranscriptomicsComparison of L. interrogans strains 56601 and IPAV at 37°C
DNA microarray analysis was used to compare the differential gene-expression profiles between Leptospira interrogans serovar Lai type strain 56601 and its corresponding attenuated strain IPAV. A 22 kb genomic island covering a cluster of 34 genes (LA0186 to LA0219) was actively expressed in both str...
ORGANISM(S): Leptospira interrogans serovar Lai str. 56601 
2010-05-25 | E-GEOD-10788 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat dorsal root ganglions treated with paclitaxel against untreated controls
L4-L5 segment dorsal root ganglion (DRG) samples from controls and the paclitaxel-induced peripheral neuropathy (PIPN) rats were collected at day 14 after the initiation of paclitaxel treatment. Paclitaxel and vehicle were administered intraperitoneally at 2 mg/kg for four consecutive days at a fina...
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13430 | biostudies-arrayexpress
TranscriptomicsNsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus
S. aureus possesses 16 two-component systems (TCS), two of which (GraRS & NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, conserved within the firmicutes. NsaRS has recently been documented as being important for nisin-resistance in S. aureus. In this study we present a d...
ORGANISM(S): Staphylococcus aureus 
2011-05-16 | E-GEOD-27061 | biostudies-arrayexpress
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