Zhong Wenjie W - OmicsDI

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Proteomics (3)
Metabolomics (1)

Organisms

Homo sapiens (3)

Repository

iProX (2)
MetaboLights (1)
pride (1)

Tissue

Cell culture (1)
Hepatocyte (1)

Disease

Obesity (1)

Technology Type

Mass spectrometry (1)
Gel-based experiment (1)
Mass Spectrometry (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2025 (2)
2024 (1)
2022 (1)

CHEBI ID

CHEBI:10055 (1)
CHEBI:101085 (1)
CHEBI:1060 (1)
CHEBI:113542 (1)
CHEBI:116314 (1)
CHEBI:125471 (1)
CHEBI:131158 (1)
CHEBI:131456 (1)
CHEBI:131659 (1)
CHEBI:131690 (1)
CHEBI:132244 (1)
CHEBI:132837 (1)
CHEBI:133013 (1)
CHEBI:133066 (1)
CHEBI:133172 (1)
CHEBI:133185 (1)
CHEBI:133657 (1)
CHEBI:133919 (1)
CHEBI:134287 (1)
CHEBI:134458 (1)
CHEBI:134485 (1)
CHEBI:134676 (1)
CHEBI:134713 (1)
CHEBI:134788 (1)
CHEBI:134841 (1)
CHEBI:134862 (1)
CHEBI:134905 (1)
CHEBI:134934 (1)
CHEBI:135118 (1)
CHEBI:135290 (1)

Metabolite Name

(+)-8'-hydroxyabscisic acid (1)
(-)-11-hydroxy-9,10-dihydrojasmonic acid 11-beta-d-glucoside (1)
(-)-lupinine (1)
(11z,14z)-eicosadienoylcarnitine (1)
(1s,2r)-1,2-dihydrodibenzo[b,d]thiophene-1,2-diol (1)
(1s,2r,3s,5s,6s,16e,18e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,16-trimethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate (1)
(2,7-dimethyloctahydro-1h-cyclopenta[c]pyridin-4-yl)methanol (1)
(2e)-2-[(4z)-5-(methylsulfanyl)-4-penten-2-yn-1-ylidene]-1,6-dioxaspiro[4.4]non-3-ene (1)
(2r,3s)-2-methylcitric acid (1)
(2s,3r,4e,8e)-3-hydroxy-2-[methyl(stearoyl)amino]-4,8-octadecadien-1-yl hydrogen sulfate (1)
(2s,3s,4s,5r,6s)-6-(hydroxymethyl)-5-{[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)-5-{[(2r,3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl]oxy}tetrahydro-2h-pyran-2-yl]oxy}tetrahydro-2h-pyran-2,3,4,5-tetrol (1)
(2s,4ar,4br,6as,12bs,12cs,14as)-2-(2-hydroxy-2-propanyl)-12b,12c-dimethyl-3,4,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2h-chromeno[5',6':6,7]indeno[1,2-b]indole-4a(4bh)-carbaldehyde (1)
(2s,4s)-4-amino-2-hydroxy-2-methylpentanedioic acid (1)
(2s,4s)-pinnatanine (1)
(2z)-3-{5-[(4z)-5-(methylsulfanyl)-4-penten-2-yn-1-yl]-2-furyl}acrylaldehyde (1)
(2z,4z)-2-hydroxyhexa-2,4-dienoic acid (1)
(3-methyl-2-butenyl)-benzene (1)
(3s,5r,6s,7e,9x)-7-megastigmene-3,6,9-triol 9-glucoside (1)
(4-methylphenyl)acetaldehyde (1)
(4e,6e,d14:2) sphingosine (1)
(7s)-7-{[(2s)-9-hydroxy-2-isobutyl-3-oxo-2,3,9,9a-tetrahydro-1h-imidazo[1,2-a]indol-9-yl]methyl}-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione (1)
(9e,15e)-heptadec-9,15-trien-11,13-diyn-4-one (1)
(?)-2-methylthiazolidine (1)
(ac)2-l-lys-d-ala (1)
(r)-n-methylsalsolinol (1)
(r)-pelletierine (1)
(s)-3-octanol glucoside (1)
(s)-5'-deoxy-5'-(methylsulfinyl)adenosine (1)
(s)-menthone 8-thioacetate (1)
(x)-2-heptanol glucoside (1)

Lab affiliation

Cheeloo College of Medicine, Shandong University (1)

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Targeted protein of USP20 by LC-MS/MS in HepG2 cells

Obesity is a metabolic disease accompanied by lipid metabolism that can cause hyperlipidemia, non-alcoholic fatty liver disease, and artery atherosclerosis. Sleeve gastrectomy (SG) is a type of bariatric surgery that can effectively treat obesity and improve lipid metabolism. However, its specific u...

ORGANISM(S): Homo sapiens (Human)

2022-12-22 | PXD037693 | Pride

PRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights

Canagliflozin ameliorates progestin resistance by suppressing RARβ/CRABP2 signaling in TRβ knockout endometrial cancer cells

THRB-knockout RL95-2 (THRB(-/-)/RL95-2) cells were constructed to investigate progestin resistance mechanisms. Cell proliferation and apoptosis were assessed in RL95-2 and THRB(-/-)/RL95-2 cells treated with canagliflozin (CANA), medroxyprogesterone acetate (MPA), or their combination using CCK-8, E...

ORGANISM(S): Homo Sapiens

2025-02-07 | PXD060591 |

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy

Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...