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ProteomicsStreptococcus suis SC-19, LC-MSMS
Phosphoproteomic analysis to identify deregulated phosphoproteins in stk mutant strain compared to the parental wild type strain SC-19
ORGANISM(S): Streptococcus suis 
2017-03-27 | PXD005663 | Pride
Streptococcus suis sc-19 Lc-msms 
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
TranscriptomicsRoles of RDR701 and DCLs in Rice PhasiRNA biogenesis
In this study, we analyzed function of the rice RDR701 and various DCLs proteins in small RNA processing. small RNA deep sequencing analyses revealed that RDR701 and OsDCL4 is involved in tasiRNAs and 21- and 24-nt phasiRNAs biogenesis. Further analyses indicate RDR701 coupling with OsDCL4 and OsDCL...
ORGANISM(S): Oryza sativa 
2012-07-02 | E-GEOD-26405 | biostudies-arrayexpress
TranscriptomicsDCL4-Dependent Clusters of PhasiRNAs in Rice.
The osdcl4-1 mutant exhibits much severer developmental defects than dcl4 in Arabidopsis, suggesting that Os DCL4 may process broader substrates in rice. By deep sequencing of small RNAs from different tissues of wild types and osdcl4-1, we revealed that 21-nucleotide siRNAs were largely dependent o...
ORGANISM(S): Oryza sativa 
2012-03-29 | E-GEOD-22763 | biostudies-arrayexpress
ProteomicsProteomic analysis of radioiodine-refractory differentiated thyroid cancer
Radioiodine refractory differentiated thyroid cancer (RR-DTC) is the main factor affecting the overall survival rate of thyroid cancer clinically. In order to investigate its underlying molecular mechanism of pathogenesis with the hope to explore novel therapeutic targets for clinical treatment, we ...
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037968 |
ProteomicsMS Analysis Reveals the Potential Signaling Pathway for RFWD2 Function in multiple myeloma
MS was conducted to assess activation of RFWD2-related signaling pathways.
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024507 |
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo Sapiens 
2025-10-09 | PXD069246 |
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