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TranscriptomicsMechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch
Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. mel...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8803 | biostudies-arrayexpress
TranscriptomicsEffect of Carbon Dioxide on Neonatal Mouse Lung: A Genomic Approach
Rationale: Despite the deleterious effects associated with elevated carbon dioxide (CO2), or hypercapnia, it has been hypothesized that CO2 can protect the lung from injury. However, the effects of chronic hypercapnia on the neonatal lung are unknown. Objectives: To determine whether chronic hyperca...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3161 | biostudies-arrayexpress
ProteomicsProteomic of XFZYD Treat Rat Traumatic brain injury with Tandem Mass Tags,We applied TMTs to detect DEPs,and finally screened 105 overlapping DEPs,among them, there were 17 reversal proteins.According to the bio-function analysis
We applied TMTs to detect and study DEPs in the brain cortex of rats in the acute phase of the TBI and revealed the possible mechanism of XFZYD in the treatment of TBI based on bioinformatics analysis.
ORGANISM(S): Rattus norvegicus (Rat) 
2020-04-17 | PXD014923 | Pride
Rat Tbi Tmt Xfzyd 
UnknownShen-Yuan-Dan Capsule Attenuates Verapamil-Induced Zebrafish Heart Failure and Exerts Antiapoptotic and Anti-Inflammatory Effects via Reactive Oxygen Species-Induced NF-κB Pathway.
Not available
S-EPMC7959770 | biostudies-literature
TranscriptomicsDistinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster
Background: Constant hypoxia (CH) and intermittent hypoxia (IH) occur during several pathological conditions such as asthma and obstructive sleep apnea. Our research is focused on understanding the molecular mechanisms that lead to injury or adaptation to hypoxic stress using Drosophila as a model ...
ORGANISM(S): Drosophila melanogaster 
2009-04-30 | E-GEOD-14981 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Hyperoxia-Tolerant Drosophila melanogaster
One of the critical substances that mammals highly regulate via the respiratory, cardiovascular and neurologic systems is O2. Both low and high O2 levels can induce major morbidities as well as mortality. Indeed, O2 has been often considered as both an elixir and a poison in humans. In current study...
ORGANISM(S): Drosophila melanogaster 
2010-07-30 | E-GEOD-12160 | biostudies-arrayexpress
MetabolomicsAlterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodbor...
2021-04-13 | MTBLS1918 | MetaboLights
TranscriptomicsAnti-microbial peptides increase tolerance to oxidant stress in Drosophila melanogaster
It is well appreciated that reactive oxygen species (ROS) are deleterious to mammals, including humans, especially when generated in abnormally large quantities from cellular metabolism. Whereas the mechanisms leading to the production of ROS are rather well delineated, the mechanisms underlying tis...
ORGANISM(S): Drosophila melanogaster 
2010-12-21 | E-GEOD-23902 | biostudies-arrayexpress
UnknownCytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.
Not available
S-EPMC11462933 | biostudies-literature
UnknownAssociations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
Not available
S-EPMC11771664 | biostudies-literature
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