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ProteomicsMyeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity
In this study, we found that myeloid PTEN can determine chemotherapy responsiveness by promoting NLRP3-dependent antitumor immunity and suggest that it might be a potential biomarker to predict the chemotherapy responses and manipulating NLRP3/IL-1might be able to overcome the chemotherapy resista...
ORGANISM(S): Homo Sapiens 
2020-04-16 | PXD018597 |
ProteomicsQuantitative Proteomic Atlas of Ubiquitination in Hepatocellular Carcinoma
Ubiquitination plays a critical role in human hepatocellular carcinoma (HCC) genesis and metastasis, but how these processes affect systemic ubiquitinome still remains unclear. In this study, our dataset of around 12,000 diGly modified sites was identified providing a valuable insight into HCC. We f...
ORGANISM(S): Homo Sapiens 
2020-04-14 | PXD011895 |
ProteomicsHSV1 ICP0 associated ubiquitination modulation in N2A neuron cells
Proteome-wide survey of ubiquitination modulation in N2A neuron cells in response to HSV1 ICP0 transfection and HSV1 infection
ORGANISM(S): Homo Sapiens Human Herpesvirus 1 Mus Musculus 
2021-01-17 | PXD019782 |
ProteomicsQuantitative proteomic data of hepatocellular carcinoma
Ubiquitination plays a critical role in human cancer genesis and metastasis, but how the systemic ubiquitinome changes during these processes remains unclear. In this study, our dataset of approximately 12,000 identified ubiquitinated sites provided valuable insight into human hepatocellular carcino...
ORGANISM(S): Homo Sapiens 
2020-04-16 | PXD018593 |
ProteomicsIntegrative proteomics of macrophage in response to LPS stimulation
PTM proteomics had been increasingly used in studies related to inflammation and immunity, but the integrated analysis of multiple PTM was lacking. Here, we integrated WCP, acetylome, phosphoproteome and ubiquitinome datasets to identify LPS stimulation-dependent PTM events in macrophages with or wi...
ORGANISM(S): Homo Sapiens Mus Musculus 
2019-09-20 | PXD015527 |
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