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ProteomicsMulti-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress
Background: Human bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine. Identifying key factors that regulate hBMSCs osteogenic differentiation is ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD067569 | Pride
Osteogenic differentiation Proteomics Bone marrow mesenchymal stromal cells Oxidative stress Transcriptomics 
MetabolomicsNMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice (NMR assay)
In the present study, both untargeted and targeted metabolomics approaches were used to evaluate the subacute effects of hexabromocyclododecane (HBCD) on mice urine metabolome. Untargeted metabolomics based on 1H NMR showed that HBCD exposure disturbed mice metabolism in both dosed groups, especiall...
2015-02-14 | MTBLS166 | MetaboLights
ProteomicsRice OsFIE2-FLAG IP-MS analysis
To analyze the interaction proteins of Polycomb complex PRC2 in rice, we used the FIE2-FLAG transgenic material to perform IP-MS analysis.
ORGANISM(S): Oryza Sativa 
2022-04-22 | PXD033370 |
ProteomicsDifferential Membrane Protein Profile in Sperm
We investigated the differential expression of the total membrane proteins of the two sperm types by using high-purity X- and Y-sperm from 20 Holstein bulls and applying the label-free proteomic technique.
ORGANISM(S): Bos Taurus 
2021-05-18 | PXD019435 |
ProteomicsiTRAQ-based quantitative analysis of age-specific variation in salivary proteome of caries-susceptible individuals
Human saliva is a protein-rich, easily accessible source of potential biomarkers for the diagnosis of oral and systemic diseases. However, little is known about the changes in salivary proteome associated with aging of patients with dental caries. Herein, we applied iTRAQ-based quantitative approach...
ORGANISM(S): Homo Sapiens 
2018-09-12 | PXD011067 |
ProteomicsColleterial glands and ootheca proteome
In this study, the fresh oothecae used for proteomics analysis were obtained from American cockroach. Proteomics and PRM analysis were used for the identification of the oothecal proteins including the structural proteins and key enzymes.
ORGANISM(S): Gryllinae Locusta Migratoria Hierodula Patellifera Periplaneta Americana 
2022-02-22 | PXD031823 |
ProteomicsAnnexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
Annexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
ORGANISM(S): Mus Musculus 
2025-09-22 | PXD068704 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD045174 |
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