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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
ProteomicsImmunoprecipitation-Mass Spectrometry (IP-MS) of SRPK1 in endothelial cells
To identify the E3 ubiquitin ligase responsible for the polyubiquitination of SRPK1, we performed immunoprecipitation (IP) using an anti-SRPK1 antibody or IgG control as well as endothelial lysates treated with PA and MG-132, followed by mass spectrometry analysis
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-30 | PXD062417 | Pride
Rat Endothelial cells Lc-ms/ms 
ProteomicsPsychological stress exacerbates vitiligo via dysregulated proteolysis of substance P and MRGPRX2-dependent mast cell activation
Although psychological stress has been anecdotally related to flare-ups of vitiligo, the underlying mechanism(s) has remained poorly defined. In this study, we investigated whether substance P (SP) and its proteolytic fragments (SP1-9 and SP1-7) modulate the anti-melanocyte immune response under str...
ORGANISM(S): Homo Sapiens 
2025-11-07 | PXD070437 |
ProteomicsSpatiotemporally direct capturing global substrates of post-translational modifying enzymes in living cells
Methods for direct capturing global substrates of protein-modifying enzymes in living cells are with many challenges, and yet largely unexplored. Here, we report a strategy to directly capture substrates of protein-modifying enzymes via PTM-acceptor residue crosslinking in living cells, enabling glo...
ORGANISM(S): Escherichia Coli 
2023-02-22 | PXD040318 |
ProteomicsSpatial-region-resolved proteomic map reveals mechanism of COVID-19-associated heart injury
Coronavirus disease 2019 (COVID-19) induces diverse clinical manifestations accompanied by multi-organ dysfunction. Of these, heart complications are the most life threatening. Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drive systemic ...
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031249 |
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