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ProteomicsSLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
To explore whether creatine regulates iron death sensitivity in colorectal cancer by modulating the function of certain proteins, we performed immunoprecipitation experiments with biotin-labelled creatine and conducted proteomics studies on these IP-down proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-09-06 | PXD061637 | Pride
Tumor metabolic reprogramming  ferroptosis  creatine  immunotherapy 
ProteomicsInhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer
To explore the role of Dusp18 in regulating the immune microenvironment of colorectal cancer (CRC), we established MC38 knockdown via shRNA and performed the proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2024-07-12 | PXD053284 | Pride
Mouse Crc 
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
ProteomicsCanagliflozin ameliorates progestin resistance by suppressing RARβ/CRABP2 signaling in TRβ knockout endometrial cancer cells
THRB-knockout RL95-2 (THRB(-/-)/RL95-2) cells were constructed to investigate progestin resistance mechanisms. Cell proliferation and apoptosis were assessed in RL95-2 and THRB(-/-)/RL95-2 cells treated with canagliflozin (CANA), medroxyprogesterone acetate (MPA), or their combination using CCK-8, E...
ORGANISM(S): Homo Sapiens 
2025-02-07 | PXD060591 |
ProteomicsUbiquitination Proteome of heat-killed MTB stimulated Thp-1-derived macrophages
This project analyzed the ubiquitination proteome of heat-killed MTB stimulated and unstimulated macrophages.
ORGANISM(S): Homo Sapiens 
2023-02-07 | PXD039906 |
ProteomicsMulti-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have acceptab...
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061119 |
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