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UnknownIdentification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens.

Background

The aim of this study is to screen single nucleotide polymorphisms (SNP) of chicken Calpain3 (CAPN3) gene and to analyze the potential association between CAPN3 gene polymorphisms and carcass traits in chickens. We screened CAPN3 single nucleotide polymorphisms (SNP) in 307 meat-t...
S-EPMC2656522 | biostudies-literature
UnknownIRF4 regulates myeloid-derived suppressor cells expansion and function in Schistosoma japonicum-infected mice.

Background

Interferon regulatory factor 4 (IRF4) is a crucial member of the IRF family of transcription factors and is pivotal in orchestrating the body's defense against tumors and infections by modulating the differentiation and functionality of immune cells. The role of IRF4 in mice durin...
S-EPMC11605884 | biostudies-literature
UnknownRBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing.
The prognosis for patients with metastatic bladder cancer (BCa) is poor, and it is not improved by current treatments. RNA-binding motif protein X-linked (RBMX) are involved in the regulation of the malignant progression of various tumors. However, the role of RBMX in BCa tumorigenicity and progress...
S-EPMC8049873 | biostudies-literature
UnknownKNSTRN Is a Prognostic Biomarker That Is Correlated with Immune Infiltration in Breast Cancer and Promotes Cell Cycle and Proliferation.
Kinetochore-localized astrin/SPAG5-binding protein (KNSTRN) promotes the progression of bladder cancer and lung adenocarcinoma. However, its expression and biological function in breast cancer remain largely unknown. Therefore, this study aimed to analyze KNSTRN expression, prognoses, correlation wi...
S-EPMC11427568 | biostudies-literature
UnknownZNF276 promotes the malignant phenotype of breast carcinoma by activating the CYP1B1-mediated Wnt/β-catenin pathway.
Zinc finger proteins (ZNFs) have been demonstrated to participate extensively in breast cancer progression by functioning as transcription factors, but there are still a variety of ZNFs whose biological mechanisms remain unknown. Here, we show that zinc finger protein 276 (ZNF276) is highly expresse...
S-EPMC9463175 | biostudies-literature
UnknownMacrophage marker gene-driven prognostic models for esophageal cancer: integrating multi-omics analysis and therapeutic strategies.
By integrating single-cell and bulk RNA-sequencing data for esophageal cancer (ESCA), we developed and validated a seven-macrophage-gene prognostic signature (FCN1, SCARB2, ATF5, PHLDA2, GLIPR1, CHORDC1, and BCKDK). This signature effectively stratified patients into high- and low-risk groups with s...
S-EPMC12411374 | biostudies-literature
UnknownPerformance of an AI prediction tool for new-onset atrial fibrillation after coronary artery bypass grafting.

Background

There is lack of tools to predict new-onset postoperative atrial fibrillation (NOAF) after coronary artery bypass grafting (CABG). We aimed to develop and validate a novel AI-based bedside tool that accurately predicts predict NOAF after CABG.

Methods

Data from 2994 patient...
S-EPMC11908608 | biostudies-literature
UnknownApigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells.
Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging ...
S-EPMC6438929 | biostudies-literature
UnknownN-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.
N-n-Butyl haloperidol iodide (F2) is a novel compound that has antiproliferative and antifibrogenic activities. In this study we investigated the therapeutic potential of F2 against liver fibrosis in mice and the underlying mechanisms. Two widely used mouse models of fibrosis w...
S-EPMC8724321 | biostudies-literature
UnknownConstruction and validation of a fatty acid metabolism-related gene signature for predicting prognosis and therapeutic response in patients with prostate cancer.

Background

Reprogramming of fatty acid metabolism is a newly-identified hallmark of malignancy. However, no studies have systematically investigated the fatty acid metabolism related-gene set in prostate cancer (PCa).

Methods

A cohort of 381 patients with gene expression and clinical ...
S-EPMC9910187 | biostudies-literature
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