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ProteomicsS. japonicum exosome-like vesicles LC-MS/MS
Secreted extracellular vesicles play an important role in pathogen-host interactions. Increased knowledge of schistosome extracellular vesicles could provide insights into schistosome-host interactions and enable the development of novel intervention strategies to inhibit parasitic processes and les...
ORGANISM(S): Schistosoma japonicum (Blood fluke) 
2018-10-27 | PXD003364 | Pride
S. japonicum exosome lc-ms/ms 
ProteomicsStructural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes an extensively glycosylated surface spike (S) protein to mediate host cell entry and the S protein glycosylation plays key roles in altering viral binding/function and infectivity. However, the molecular structures and glycan hete...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-27 | MSV000087891 | MassIVE
ProteomicsMass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation
S-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in ...
ORGANISM(S): Mus Musculus 
2024-03-12 | PXD050569 |
ProteomicsAnalysis of 13(S)-HODE binding proteins in hepatocyte
Here we are using proteomics analyses to try to identify proteins binding to 13(S)-HODE.
ORGANISM(S): Mus musculus (Mouse) 
2023-11-14 | PXD046933 | Pride
Hepatocyte 13(s)-hode Pull down 
TranscriptomicsTranscription profiling of S. cerevisiae cultures treated with the saponins tomatidine, tomatine or the sterol biosynthesis inhibitory compound fenpropimorph
Genome-wide expression profiling was used to identify genes that showed altered expression in response to treatment with the saponins tomatidine, tomatine and the sterol biosynthesis inhibitory compound fenpropimorph; Growth inhibition by the compounds was monitored by measuring the OD600nm. Cells w...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-21 | E-GEOD-4669 | biostudies-arrayexpress
GenomicsBas1 and Ino4 ChIP-seq
Meiotic recombination is initiated by developmentally programmed DNA double-strand breaks (DSBs). In S. cerevisiae, the vast majority of DSBs occur in the nucleosome-depleted regions at gene promoters, where transcription factors (TFs) bind. It has been proposed that TF binding can stimulate DSB for...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-21 | E-GEOD-67912 | biostudies-arrayexpress
ProteomicsTetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enzymatic uncoupling are determined by the NO synthas...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD010430 | Pride
Biotin switch S-nitrosylation 
Transcriptomicsextracellular calcium chelation experiment_P. falciparum (lab strain 3d7) schizonts treated with ionomycin vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33835 | biostudies-arrayexpress
Transcriptomicsextracellular calcium chelation experiment_P. falciparum (lab strain 3d7) schizonts treated with EGTA and ionomycin vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33836 | biostudies-arrayexpress
Transcriptomics3' RNA-Seq (3'SEQ) analysis gene expression profiling at G1-S transition in human embryonic stem cells (hESCs) and hESC-derived endoderm cells
In this report, we examine transcripts on a genome-wide level between the synchronized cell cycles of hESCs and hESC-derived endoderm cells. We found 10347, 10299 and 10362 genes expressed in the G1, G1/S, and S phase of hESCs, respectively; 10333, 10227 and 10215 genes expressed at the G1, G1/S and...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-47117 | biostudies-arrayexpress
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