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ProteomicsProbing substrate water access through the O1 channel of Photosystem II by single site mutations and membrane inlet mass spectrometry
Light-driven water oxidation by photosystem II sustains life on Earth by providing the electrons and protons for the reduction of CO2 to carbohydrates and the molecular oxygen we breathe. The inorganic core of the oxygen evolving complex is made of the earth-abundant elements manganese, calcium and ...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2025-05-07 | PXD061921 | Pride
Photosystem ii Mass spectrometry Thermosynechococcus vestitus O1 channel 
ProteomicsNigericin induced paraptosis-like cell death instead of pyroptosis in corneal keratocytes
Corneal wound healing involves complex cellular processes, including keratocyte cell death, which plays a pivotal role in initiating tissue repair. Recent studies suggest that pyroptosis, characterized by the release of pro-inflammatory factors, occurs during tissue repair which may also contribute ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD058468 | Pride
Proteomics Corneal keratocytes Nigericin 
ProteomicsMechanical loading modulates AMPK and mTOR signaling in myoblasts
Skeletal muscle adaptation to exercise involves various phenotypic changes that enhance metabolic and contractile functions. One key regulator of these adaptive responses is the activation of AMPK, influenced by exercise intensity. However, the mechanistic understanding of AMPK activation during exe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050925 | Pride
Lc-ms L6 muscle cells Mechanical loading 
ProteomicsFrancisella tularensis virulence is dependent on a conserved putative catalytic triad within the Type VI secretion system component PdpC
Many Gram-negative bacteria utilize the ubiquitous and versatile type VI secretion systems (T6SS) for diverse purposes, such as outcompeting other microbes or to successfully colonize hosts. T6SS of common pathogens are classified as T6SSi, but an outlier is the T6SSii and it is present only in the ...
ORGANISM(S): Francisella tularensis subsp. novicida (strain U112) 
2026-03-09 | PXD059583 | Pride
Virulence Type vi secretion system Amino acid triad Francisella tularensis Pdpc 
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