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ProteomicsMoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae
A convergent screening strategy was employed to systematically identify mitophagy regulators within the IMM. The quantitative proteomic comparison between the WT and ΔMoatg1 mutant under nutrient-replete (CM) and nitrogen-starvation (CM-N) conditions was conducted using TMT-labeled quantitative prot...
ORGANISM(S): Pyricularia oryzae 70-15 
2026-09-14 | PXD075441 | Pride
Mitophagy Succinylation Cox6 Fungicide Magnaporthe oryzae 
Unknown5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients.

Background

Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are responsive to the scheme, and there is no effective method to predict treatmen...
S-EPMC7879534 | biostudies-literature
UnknownBendamustine treatment of Chinese patients with relapsed indolent non-Hodgkin lymphoma: a multicenter, open-label, single-arm, phase 3 study.

Background

Bendamustine was approved in China on May 26th, 2019 by the National Medical Product Administration for the treatment of indolent B-cell non-Hodgkin lymphoma (NHL). The current study was the registration trial and the first reported evaluation of the efficacy, safety, and pharmaco...
S-EPMC8183773 | biostudies-literature
ProteomicsRegion-Resolved Proteomic Map of the Human Brain: Functional Interconnections and Neurological Implications
While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions based on regional protein expression remains limited. Here, we construct a proteomic map from thirteen anatomical brain regions of eight cadaver donors to ...
ORGANISM(S): Homo Sapiens 
2025-12-08 | PXD034484 |
ProteomicsCOVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy
Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19). However, the morphologic features, pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection. In this study, neuropathological damages and...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD038748 |
ProteomicsSpatial-region-resolved proteomic map reveals mechanism of COVID-19-associated heart injury
Coronavirus disease 2019 (COVID-19) induces diverse clinical manifestations accompanied by multi-organ dysfunction. Of these, heart complications are the most life threatening. Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drive systemic ...
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031249 |
UnknownClopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.

Importance

Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking.

Obj...

S-EPMC10928538 | biostudies-literature
UnknownToripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.

Importance

With the programmed cell death protein 1 (PD-1) blockade toripalimab, omitting highly toxic concurrent cisplatin may be feasible for nasopharyngeal carcinoma (NPC) without compromising survival.

Objective

To evaluate the efficacy and safety of toripalimab incorporated into ...
S-EPMC12371549 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.

Background

The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.

Methods

A global expert response study was co...
S-EPMC7272903 | biostudies-literature
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