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UnknownRandomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.

Purpose

To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC).

Patients...

S-EPMC5569675 | biostudies-literature
ProteomicsIntegrated Proteogenomic Characterization of Adenocarcinoma of the esophagogastric junction
In this study, we performed comprehensive genomic, transcriptomic, proteomic, and phosphorylation analysis of tumor tissues and paired normal adjacent tissues (NATs) of AEG. we describe integrative proteogenomic analyses of the largest cohort to date of AEG samples that focused particularly on novel...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD030725 | Pride
Adenocarcinoma of the esophagogastric junction，aeg，lc-ms/ms Proteogenomic 
ProteomicsIntegrated Proteogenomic Characterization of Adenocarcinoma of the esophagogastric junction
In this study, we performed comprehensive genomic, transcriptomic, proteomic, and phosphorylation analysis of tumor tissues and paired normal adjacent tissues (NATs) of AEG. we describe integrative proteogenomic analyses of the largest cohort to date of AEG samples that focused particularly on novel...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD030667 | Pride
Adenocarcinoma of the esophagogastric junction，aeg，lc-ms/ms Proteogenomic 
UnknownTotal Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo.
Doxorubicin has cardiotoxic effects that limit its clinical benefit in cancer patients. This study aims to investigate the protective effects of the total flavonoids from Clinopodium chinense (Benth.) O. Ktze (TFCC) against doxorubicin- (DOX-) induced cardiotoxicity. Male rats were intraperitoneally...
S-EPMC4346128 | biostudies-literature
UnknownAtherogenic dyslipidaemia and cardiovascular events in patients with diabetes or pre-diabetes and stable coronary artery disease: a prospective, cohort study.

Objective

The aim of the study was to investigate the impacts of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) dyslipidaemia on prognosis in coronary artery disease (CAD) patients with different glucose metabolism status.

Design

An observational cohort study.

S...

S-EPMC7813370 | biostudies-literature
UnknownIntegrative proteomic characterization of adenocarcinoma of esophagogastric junction.
The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics and phosphoproteomics profiling of 103 AEG tumors with paired normal adjacent tissues (NATs),...
S-EPMC9922290 | biostudies-literature
UnknownChrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.

Objective

Mucosal immunization was an effective defender against pathogens. Nasal vaccines could activate both systemic and mucosal immunity to trigger protective immune responses. However, due to the weak immunogenicity of nasal vaccines and the lack of appropriate antigen carriers, very fe...
S-EPMC9947463 | biostudies-literature
UnknownDesign principles of practical industrial-scale layered oxide cathodes with air/water stability for sustainable sodium-ion batteries.
Low-cost manganese-based oxides as promising cathodes for sodium-ion batteries still face significant challenges, including irreversible phase transition, air/water sensitivity, and low initial charge capacity. Herein, we precisely design a titanium-substituted Mn-based oxide cathode material with o...
S-EPMC12647261 | biostudies-literature
UnknownSingle-dose GC101 gene therapy for spinal muscular atrophy types II and III: an open-label single-arm study.
QUICK TAKE.
S-EPMC12433340 | biostudies-literature
UnknownGenome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis.
Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral density (BMD), poor bone geometry, and/or osteoporotic fractures (OF). Copy-number variation (CNV) has been shown to be associated with complex human diseases. The contribution of CNV to osteoporosis has not been d...
S-EPMC2667994 | biostudies-literature
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