Sort   by:  
 Page size 
UnknownClinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis.
Cryptococcal meningitis (CM) is a global disease with significant morbidity and mortality. Although low peripheral blood cluster of differentiation 4 (CD4) cell counts are found to be related to a high burden of cryptococcus in HIV-infected patients, little is known about possible immune defects in ...
S-EPMC4753916 | biostudies-literature
UnknownThe immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke.
Through considerable effort in research and clinical studies, the immune system has been identified as a participant in the onset and progression of brain injury after ischaemic stroke. Due to the involvement of all types of immune cells, the roles of the immune system in stroke pathology and associ...
S-EPMC7814595 | biostudies-literature
UnknownMechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes.
Recently, the asymmetric bifunctionalization of alkenes has received much attention. However, the development of enantioselective alkoxyalkenylation has posed a considerable challenge and has lagged largely behind. Herein, we report a new palladium-catalyzed enantioselective alkoxyalkenylation react...
S-EPMC10665319 | biostudies-literature
UnknownHIT: linking herbal active ingredients to targets.
The information of protein targets and small molecule has been highly valued by biomedical and pharmaceutical research. Several protein target databases are available online for FDA-approved drugs as well as the promising precursors that have largely facilitated the mechanistic study and subsequent ...
S-EPMC3013727 | biostudies-literature
UnknownSulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway.
Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2). But the molecular mechanisms underlying the beneficial effect of SFN in the treatment of NAFLD remain controversial. Fibroblast g...
S-EPMC9159986 | biostudies-literature
UnknownRecombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment.
Immune checkpoint inhibitors (ICIs) have significantly advanced the field of cancer immunotherapy. However, clinical data has shown that many patients have a low response rate or even resistance to immune checkpoint inhibitor alone. The underlying reasons for its poor efficacy include the deficiency...
S-EPMC11805834 | biostudies-literature
UnknownMutation Landscape of Base Substitutions, Duplications, and Deletions in the Representative Current Cholera Pandemic Strain.
Pandemic cholera is a major concern for public health because of its high mortality and morbidity. Mutation accumulation (MA) experiments were performed on a representative strain of the current cholera pandemic. Although the base-pair substitution mutation rates in Vibrio cholerae (1.24 × 10-10 per...
S-EPMC6105331 | biostudies-literature
UnknownFasting blood glucose-to-glycated hemoglobin ratio and all-cause mortality among Chinese in-hospital patients with acute stroke: a 12-month follow-up study.

Background

Stroke is a leading cause of death and functional impairment in older people. To assess the prospective association between fasting blood glucose-to-glycated hemoglobin ratio and all-cause mortality and poor prognosis in stroke patients.

Methods

A total of 971 Chinese inpat...
S-EPMC9210760 | biostudies-literature
UnknownmTORC1 Signaling Pathway Mediates Chronic Stress-Induced Synapse Loss in the Hippocampus.
Background: The mechanistic target of rapamycin complex 1 (mTORC1) signaling has served as a promising target for therapeutic intervention of major depressive disorder (MDD), but the mTORC1 signaling underlying MDD has not been well elucidated. In the present study, we investigated whether mT...
S-EPMC8722735 | biostudies-literature
UnknownSitravatinib plus tislelizumab in locally recurrent or metastatic triple-negative breast cancer: a multi-cohort, single-arm, phase II clinical trial (SPARK Trial).
Not available
S-EPMC12831270 | biostudies-literature
Sort   by:  
 Page size