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UnknownSaccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury.
Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes a promising therapy for hepatosis. In this study, we aimed to investigate the protective effects of S. b...
S-EPMC5430957 | biostudies-literature
UnknownUSP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance.
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment. However, the underlying mechanism of NPC radioresistance remains poorly understood, and the promising radiosensitizer for NPC radiotherapy is also lacked. Overexpression of USP5 and EphA2 has been linked to various ...
S-EPMC11781186 | biostudies-literature
UnknownHemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN-γ Signaling.
Hematopoietic stem and progenitor cells (HSPCs) possess the remarkable ability to regenerate the whole blood system in response to ablated stress demands. Delineating the mechanisms that maintain HSPCs during regenerative stresses is increasingly important. Here, it is shown that Hemgn is significan...
S-EPMC8844507 | biostudies-literature
UnknownAnti-CTLA-4 m2a Antibody Exacerbates Cardiac Injury in Experimental Autoimmune Myocarditis Mice By Promoting Ccl5-Neutrophil Infiltration.
The risk for suffering immune checkpoint inhibitors (ICIs)-associated myocarditis increases in patients with pre-existing conditions and the mechanisms remain to be clarified. Spatial transcriptomics, single-cell RNA sequencing, and flow cytometry are used to decipher how anti-cytotoxic T lymphocyte...
S-EPMC11425905 | biostudies-literature
UnknownViral integration drives multifocal HCC during the occult HBV infection.

Background & aims

Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the mechanism of life-long Integration of virus DNA into OBI host's ge...
S-EPMC6570863 | biostudies-literature
ProteomicsiTRAQ-based Quantitative Proteomic Analysis of Thoracic Aortic from Adult Rats Born to Pre-eclamptic Mothers
Epidemiological studies suggest that both preeclampsia and gestational hypertension could lead to offspring with vascular dysfunction. Previously, we have analyzed the protein profile of umbilical artery tissue from preeclampsia patients. In order to gain insights into the mechanisms of vascular dys...
ORGANISM(S): Rattus Rattus 
2021-03-18 | PXD024811 |
UnknownRibosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting cancer stem-like cell (CSC) properties that contribute to therapeutic resistance including radioresistance, but the molecula...
S-EPMC7410060 | biostudies-literature
UnknownCorrelation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study.
Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, the composition of the gut microbiota is non-invasively tested and altered in patients with ITP. This study aims to develop a predictive model t...
S-EPMC12165022 | biostudies-literature
UnknownDeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning.
General reasoning represents a long-standing and formidable challenge in artificial intelligence (AI). Recent breakthroughs, exemplified by large language models (LLMs)1,2 and chain-of-thought (CoT) prompting3, have achieved considerable success on foundational reasoning tasks....
S-EPMC12443585 | biostudies-literature
UnknownComparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants.
A two-marker combination of plastid rbcL and matK has previously been recommended as the core plant barcode, to be supplemented with additional markers such as plastid trnH-psbA and nuclear ribosomal internal transcribed spacer (ITS). To assess the effectiveness and universality of these barcode mar...
S-EPMC3241788 | biostudies-literature
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