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ProteomicsADAMTS12 serves as a checkpoint in fibrosis that controls migration and expansion of injury-responsive fibroblasts
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-sequencing (scRNA-seq) technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD040152 | Pride
Fibrosis Adamts12 Extracellular matrix 
ProteomicsA Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with ad...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-11 | PXD004671 | Pride
T cell tolerance Foxp3 Cold exposure 
UnknownNovel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia.
Not available
S-EPMC11000665 | biostudies-literature
UnknownA Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Not available
S-EPMC6014557 | biostudies-literature
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