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TranscriptomicsCharting a dynamic DNA methylation landscape of the human genome
DNA methylation is a defining feature of mammalian cellular identity and is essential for normal development. Most cell types, except germ cells and pre-implantation embryos, display relatively stable DNA methylation patterns, with 70-80% of all CpGs being methylated. Despite recent advances we stil...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-46644 | biostudies-arrayexpress
GenomicsTranscriptional and Epigenetic Dynamics During Specification of Human Embryonic Stem Cells
Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the epigenetic mechanisms that facilitate cellular transitions in a human context. To that end, we performed comprehensive transcriptional and epigenetic profiling of early populations derived through direct...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-46130 | biostudies-arrayexpress
GenomicsIn Vivo and In Vitro Dynamics of Undifferentiated Embryonic Cell Transcription Factor 1
Pluripotent stem cells retain the ability differentiate into the three germ layers and germ line. As a result, there is a major interest in characterizing regulators that establish and maintain pluripotency. The network of transcription factors continues to expand in complexity, and one factor, Undi...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-53768 | biostudies-arrayexpress
TranscriptomicsGeneration of organized anterior foregut epithelia from pluripotent stem cells using small molecules
Anterior foregut endoderm (AFE) gives rise to many tissue types of interest for therapeutic research including the esophagus, salivary glands, lung, thymus, parathyroid and thyroid. Despite its importance, only few reports describe the generation of AFE from pluripotent stem cells (PSCs) by directed...
ORGANISM(S): Mus musculus 
2013-04-15 | E-GEOD-42139 | biostudies-arrayexpress
GenomicsGenomic distribution and inter-sample variation of non-CG methylation across human cell types
DNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the total DNA methylation content in human and mouse cells. While the genomic distributio...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-27432 | biostudies-arrayexpress
TranscriptomicsDissecting neural differentiation regulatory networks through epigenetic footprinting
Human pluripotent stem cell derived models that accurately recapitulate neural development in vitro and allow for the generation of specific neuronal subtypes are of major interest to the stem cell and biomedical community. Notch signaling, particularly through the Notch effector HES5, is a major p...
ORGANISM(S): Homo sapiens 
2014-11-02 | E-GEOD-62193 | biostudies-arrayexpress
UnknownIntegrative analysis of 111 reference human epigenomes.
Not available
S-EPMC4530010 | biostudies-literature
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