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MetabolomicsMapping human microbiome drug metabolism by gut bacteria and their genes

Individuals vary widely in their drug responses, which can be dangerous and expensive due to treatment delays and adverse effects. Growing evidence implicates the gut microbiome in this variability, however the molecular mechanisms remain largely unknown. We measured the ability of 76 diverse hum...

2019-07-10 | MTBLS896 | MetaboLights
UnknownTemple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity?
Not available
S-EPMC4901505 | biostudies-literature
UnknownZimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis.
Not available
S-EPMC6783959 | biostudies-literature
ProteomicsEvaluation of promoter sequences for the secretory production of a Clostridium thermocellum cellulase in Paenibacillus polymyxa
Due to the high capacity of their secretion machinery Gram-positive bacteria from the genus Bacillus are important expression hosts for the high-yield production of enzymes in industrial biotechnology. However, to date strains from only a few Bacillus species are used for enzyme production at the in...
ORGANISM(S): Paenibacillus polymyxa 
2018-09-05 | PXD009882 | Pride
Secretome analysis Strain development Cel8a Heterologous expression Medium optimization Signal peptide 
UnknownIodination of cyclo-E5 -Complexes (E=P, As).
Not available
S-EPMC7540426 | biostudies-literature
UnknownFKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls.
Not available
S-EPMC4360217 | biostudies-literature
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Using the global SILAC and label-free phosphoproteomics experiments as a basis, an inclusion list for validation of known and novel AKT, RSK and S6K targets comprising the RxRxxp[ST] motif was generated. Samples were analyzed by PRM-MS.
ORGANISM(S): Mus Musculus 
2023-02-27 | PXD035962 | panorama
ProteomicsmRNA targeting to the human ER
Besides targeting of precursor polypeptides to the human endoplasmic reticulum (ER), mRNAs are targeted to the ER. While the first targeting process is reansonably well understood, relatively little is known about the latter. To obtain novel insights into mRNA targeting to the human ER, we combined ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD011990 | Pride
Hela Rrbp1 Ktn1 
UnknownFcγ-receptor IIIA polymorphism p.158F has no negative predictive impact on rituximab therapy with and without sequential chemotherapy in CD20-positive posttransplant lymphoproliferative disorder.
Not available
S-EPMC3987796 | biostudies-literature
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
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