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Transcription factor induced reprogramming of one specialized cell type into another is a promising approach for regenerative medicine. However, the process still remains poorly understood, in large part because of the lack of adequate experimental models. Here we describe a robust cell reprogrammin...
ORGANISM(S): Mus musculus 
Neutrophils effectively eliminate Candida albicans from human blood, but a subset of C. albicans escapes their activity and remains extracellular and viable. Here we show that this is independent from known immune-escape traits of this fungal pathogen. Instead, neutrophil-derived extracellular vesic...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD070460 | Pride
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1791 | MetaboLights

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
Fungal infections remain a tremendous source of global morbidity and mortality, with more than 1 billion individuals affected by fungal infections each year. Invasive infections are particularly dangerous and kill numbers on par with tuberculosis or malaria. Aspergillus fumigatus is a major source o...
ORGANISM(S): Aspergillus fumigatus CEA10 Homo sapiens (Human) 
2021-07-30 | PXD027032 | Pride
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