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TranscriptomicsRNAi profiling of human cells with MYC or PIM1 silencing
It has been estimated that about 11% of cellular genes present a functional E box to which MYC can associate on the genome. MYC silencing demonstrated that MYC recruits PIM1 at specific MYC binding sites and confocal microscopy following growth factor treatment, showed an elevated degree of nuclear ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7960 | biostudies-arrayexpress
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
TranscriptomicsGenome-wide analysis of the transcriptomes of mouse embryonic stem cells (mESC) maintained in different indicated conditions.
Analysis of genes involved in the mESC maintainance between different conditions of growth. The hypothesis tested in the present study was that Myc can sustain mESC self renewal and pluripotency. Results provide important information on the mechanism by which Myc supports mESC self renewal, in compa...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-58656 | biostudies-arrayexpress
ProteomicsMLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki Syndrome
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and functioning depends on multivalent interactions occurring among transcription factors, cofactors...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD021616 | Pride
Kabuki syndrome Ptm Epiprofile Histone Mass spectrometry 
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
UnknownLamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes
Not available
S-JCBD-201504035 | bioimages
UnknownChromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation
Not available
S-SCDT-10_1038-S44318-026-00884-Z | biostudies-other
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