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ProteomicsEpiProfile 2.0: a proteomics tool to quantify histone modifications by mass spectrometry
The histone LC-MS/MS data analysis is challenging due to the large number and variety of isobaric histone peptides, and the high dynamic range of histone peptide abundances. We introduce EpiProfile 2.0 to quantify histone post-translational modifications from mass spectrometry data, in which fragmen...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD004166 | Pride
Proteomics Post-translational modification Mass spectrometry Histone Quantification 
UnknownEpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data.
Not available
S-EPMC6387837 | biostudies-literature
UnknownEpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra.
Not available
S-EPMC4458730 | biostudies-literature
ProteomicsQuantifying histone PTMs by bottom-up MS
Histone post-translational modifications (PTMs) contribute to chromatin function through their chemical properties which influence chromatin structure, and their ability to recruit chromatin interacting proteins. Nanoflow liquid chromatography coupled with high resolution tandem mass spectrometry (n...
ORGANISM(S): Homo sapiens (Human) 
2015-03-27 | PXD001541 | Pride
Proteomics Post-translational modification Isobaric peptide Retention time Histone Quantification 
ProteomicsImprovements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications
Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes, although they are still decorated by post-translational modifications (PTMs). Here, we used a highly robust workflow to analyze histone PTMs in the parasite Trypanosoma cruzi using mass spectrometry-based data-ind...
ORGANISM(S): Trypanosoma cruzi cruzi 
2022-02-07 | PXD018295 | Pride
Ptm Trypanosoma cruzi Histone 
ProteomicsHISTONE data RAw files, Orbitrap machine
Mass spec, histone, lung , human, PTMS, epiprofile 2.0
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-06 | MSV000089429 | MassIVE
ProteomicsMLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki Syndrome
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and functioning depends on multivalent interactions occurring among transcription factors, cofactors...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD021616 | Pride
Kabuki syndrome Ptm Epiprofile Histone Mass spectrometry 
ProteomicsIdentification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans
This project focuses on Caenorhabditis elegans. Quantitative mass spectrometry (MS) was performed on histone H3 extracted from whole-worm samples to characterize histone H3 methylation. Wild-type and set-19 mutant backgrounds were analyzed and modification patterns were compared between the two gene...
ORGANISM(S): Caenorhabditis Elegans 
2026-01-14 | PXD073043 |
UnknownIntegrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular Signatures.
Not available
S-EPMC10380343 | biostudies-literature
UnknownMulticellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs.
Not available
S-EPMC5371507 | biostudies-literature
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