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GenomicsMeCP2 binds to mCH as neurons mature, influencing transcription and onset of Rett syndrome [ChIP-Seq]
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene encoding Methyl-CpG-binding Protein 2 (MeCP2). Despite decades of research, it remains unclear how MeCP2 actually regulates transcription or why RTT features appear only 6-18 months after birth. We exami...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-66868 | biostudies-arrayexpress
TranscriptomicsExpression data from 6 day-old Atxn1L-/- and Atxn1-/- lung tissues
Although expansion of a polyglutamine tract in ATAXIN1 (ATXN1) causes Spinocerebellar ataxia type 1, the functions of wild-type ATXN1 and ATAXIN1-Like (ATXN1L) remain poorly understood. To gain insight into the function of these proteins, we generated and characterized Atxn1L-/- and Atxn1-/- ; Atxn1...
ORGANISM(S): Mus musculus 
2011-11-06 | E-GEOD-29551 | biostudies-arrayexpress
TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsRole of Capicua in metabolic system
CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified criti...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-60375 | biostudies-arrayexpress
ProteomicsParkinson's disease mouse brain proteome profiling
We compared the proteome from a vulnerable region (Substantia nigra pars compacta, SNc) of wild-type and Parkinsonian mice to that of an adjacent, less vulnerable, region (Ventral tegmental area, VTA) and identified several proteins which exhibited both spatiotemporal- and genotype-restricted change...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-12-25 | MSV000080437 | MassIVE
ProteomicsAn Anatomically Resolved Comprehensive Mouse Brain Proteome
A mouse brain protein atlas that covers 17 surgically distinctive neuroanatomical regions of the adult mouse brain, each less than 1mm3 in size.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-06-01 | MSV000079789 | MassIVE
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